Does Digitoxin Interact with Sertraline?
Digitoxin and Sertraline have a unknown drug interaction according to U.S. FDA drug labeling data. Sertraline may cause shifts in plasma concentrations due to competition for plasma protein binding, potentially resulting in adverse effects. The mechanism involves competition for plasma protein binding. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Digitoxin and Sertraline occurs because competition for plasma protein binding. Clinically, this means sertraline may cause shifts in plasma concentrations due to competition for plasma protein binding, potentially resulting in adverse effects.
What To Tell Your Doctor or Pharmacist
If you are taking Digitoxin and your doctor is considering prescribing Sertraline (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider