Quinidine Gluconate has 26 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Digoxin, Diltiazem, Verapamil. Patients taking Quinidine Gluconate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 26
- Major
- 4
- Moderate
- 12
- Minor
- 1
Major (4)
- Quinidine Gluconate + Digoxin— Quinidine slows digoxin elimination and reduces volume of distribution, potentially doubling serum digoxin levels; digox…
- Quinidine Gluconate + Diltiazem— Diltiazem significantly decreases quinidine clearance and increases half-life, requiring monitoring of quinidine levels.
- Quinidine Gluconate + Verapamil— Verapamil significantly reduces hepatic clearance of quinidine with corresponding increases in serum levels and half-lif…
- Quinidine Gluconate + Warfarin— Quinidine potentiates warfarin's anticoagulatory action; anticoagulant dosage may need reduction.
Moderate (12)
- Quinidine Gluconate + Amiodarone— Amiodarone increases quinidine levels by unknown pharmacokinetic mechanisms.
- Quinidine Gluconate + Andthiazide— Thiazide diuretics alkalinize urine and reduce renal elimination of quinidine.
- Quinidine Gluconate + Cimetidine— Cimetidine increases quinidine levels by unknown pharmacokinetic mechanisms.
- Quinidine Gluconate + Digitoxin— Quinidine raises serum digitoxin levels, though the effect appears smaller than with digoxin.
- Quinidine Gluconate + Ketoconazole— Ketoconazole increases quinidine levels through competition for P450 IIIA4 metabolic pathway.
- Quinidine Gluconate + Mao Inhibitors— Carbonic-anhydrase inhibitors alkalinize urine and reduce renal elimination of quinidine.
- Quinidine Gluconate + Mexiletine— Quinidine may affect mexiletine metabolism via cytochrome P450 IID6 inhibition; monitoring recommended.
- Quinidine Gluconate + Phenobarbital— Phenobarbital induces cytochrome P450 IIIA4 and accelerates hepatic elimination of quinidine.
- Quinidine Gluconate + Phenytoin— Phenytoin induces cytochrome P450 IIIA4 and accelerates hepatic elimination of quinidine.
- Quinidine Gluconate + Propranolol— Propranolol may increase peak quinidine levels, decrease volume of distribution, and decrease total clearance in some st…
- Quinidine Gluconate + Rifampin— Rifampin induces cytochrome P450 IIIA4 and accelerates hepatic elimination of quinidine.
- Quinidine Gluconate + Sodium Bicarbonate— Sodium bicarbonate alkalinizes urine and reduces renal elimination of quinidine.
Minor (1)
- Quinidine Gluconate + Nifedipine— Nifedipine very rarely decreases quinidine levels by unknown mechanisms.