Does Digoxin Interact with Quinidine Gluconate?
CDI records a major classification for Digoxin and Quinidine Gluconate. The stored summary is: Quinidine slows digoxin elimination and reduces volume of distribution, potentially doubling serum digoxin levels; digoxin dose reduction usually needed. The mechanism involves decreased elimination and reduced volume of distribution. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Digoxin Class
- Cardiac Glycoside
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Decreased elimination and reduced volume of distribution
What To Tell Your Doctor or Pharmacist
If you are taking Digoxin and your doctor is considering prescribing Quinidine Gluconate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider