Tadalafil has 28 known drug interactions based on U.S. FDA drug labeling data. Of these, 9 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Hydralazine Hydrochloride And Isosorbide Dinitrate, Itraconazole, Ketoconazole. Patients taking Tadalafil should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 28
- Contraindicated
- 9
- Major
- 7
- Moderate
- 7
- Minor
- 2
Contraindicated (9)
- Tadalafil + Hydralazine Hydrochloride And Isosorbide Dinitrate— PDE5 inhibitor potentiates hypotensive effects of isosorbide dinitrate. Contraindicated.
- Tadalafil + Itraconazole— Potent CYP3A inhibitor; avoid use of tadalafil in patients taking itraconazole.
- Tadalafil + Ketoconazole— Potent CYP3A inhibitor; avoid use of tadalafil in patients taking ketoconazole.
- Tadalafil + Nitrates— Administration of tadalafil to patients using any form of organic nitrate is contraindicated. Tadalafil potentiates the …
- Tadalafil + Nitroglycerin— PDE-5 inhibitor that potentiates hypotensive effects of nitroglycerin. Contraindicated with nitroglycerin.
- Tadalafil + Nitroglycerin Lingual— PDE5 inhibitor that potentiates hypotensive effects of nitroglycerin. Concomitant use is contraindicated.
- Tadalafil + Nitroglycerin Tablet— PDE-5 inhibitor that potentiates hypotensive effects of nitroglycerin. Concomitant use is contraindicated.
- Tadalafil + Rifampin— Potent CYP3A inducer; avoid use of tadalafil in patients chronically taking rifampin.
- Tadalafil + Riociguat— Co-administration with tadalafil is contraindicated because of hypotension. Do not administer 24 hours before or within …
Major (7)
- Tadalafil + Alcohol— Substantial consumption (5+ units) with tadalafil increases potential for orthostatic signs and symptoms including incre…
- Tadalafil + Alfuzosin— Clinical pharmacology studies conducted with coadministration of tadalafil with alfuzosin. Additive blood-pressure-lower…
- Tadalafil + Alpha-Blockers— Caution advised when tadalafil is coadministered with alpha-blockers. Both are vasodilators with blood-pressure-lowering…
- Tadalafil + Doxazosin— Clinical pharmacology studies conducted with coadministration of tadalafil with doxazosin. Additive blood-pressure-lower…
- Tadalafil + Ritonavir— CYP3A4 inhibitor that increases tadalafil exposure, requiring dose adjustment: no more than 10 mg every 72 hours for as-…
- Tadalafil + Silodosin— PDE5 inhibitor that with silodosin can cause symptomatic hypotension with increased positive orthostatic test results.
- Tadalafil + Tamsulosin— Clinical pharmacology studies conducted with coadministration of tadalafil with tamsulosin. Additive blood-pressure-lowe…
Moderate (7)
- Tadalafil + Amlodipine— Small reductions in blood pressure occurred following coadministration of tadalafil with amlodipine compared with placeb…
- Tadalafil + Angiotensin Ii— Small reductions in blood pressure occurred following coadministration of tadalafil compared with placebo.
- Tadalafil + Bendroflumethiazide— Small reductions in blood pressure occurred following coadministration of tadalafil compared with placebo.
- Tadalafil + Enalapril— Small reductions in blood pressure occurred following coadministration of tadalafil compared with placebo.
- Tadalafil + Metoprolol— Small reductions in blood pressure occurred following coadministration of tadalafil compared with placebo.
- Tadalafil + Sapropterin Dihydrochloride— Both sapropterin and PDE-5 inhibitors may induce vasorelaxation, potentially reducing blood pressure.
- Tadalafil + Sepiapterin— PDE-5 inhibitor that with sepiapterin may cause additive vasorelaxation and blood pressure reduction. Monitor blood pres…
Minor (2)
- Tadalafil + Aluminum & Magnesium Hydroxides— Simultaneous administration reduced apparent rate of tadalafil absorption without altering total exposure (AUC).
- Tadalafil + Nizatidine— Increase in gastric pH from nizatidine had no significant effect on tadalafil pharmacokinetics.