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Does Tadalafil Interact with Riociguat?

Tadalafil and Riociguat have a contraindicated drug interaction according to U.S. FDA drug labeling data. Co-administration with tadalafil is contraindicated because of hypotension. Do not administer 24 hours before or within 48 hours after tadalafil. The mechanism involves pde-5 inhibitor interaction causing hypotension. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Tadalafil Class
Phosphodiesterase 5 Inhibitor
Riociguat Class
Soluble Guanylate Cyclase Stimulator
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Tadalafil and Riociguat occurs because pde-5 inhibitor interaction causing hypotension. Clinically, this means co-administration with tadalafil is contraindicated because of hypotension. do not administer 24 hours before or within 48 hours after tadalafil. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Tadalafil and your doctor is considering prescribing Riociguat (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tadalafil(Alyq)+💊 Riociguat(Adempas)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Phosphodiesterase 5 Inhibitor
Drug B class
Soluble Guanylate Cyclase Stimulator
Source
NLP:riociguat

What this means in plain English

Co-administration with tadalafil is contraindicated because of hypotension. Do not administer 24 hours before or within 48 hours after tadalafil.

About Tadalafil and Riociguat

Tadalafil is a Phosphodiesterase 5 Inhibitor, while Riociguat is a Soluble Guanylate Cyclase Stimulator. You may recognize them by the brand names Alyq and Adempas. Both medications are taken by mouth. Both Tadalafil and Riociguat carry an FDA boxed warning — the agency's most serious safety designation.

What the FDA label says

"PDE-5 inhibitor interaction causing hypotension"

📖 Source: NLP:riociguat

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.