Terbinafine has 22 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Warfarin, Warfarin Sodium, Amiodarone. Patients taking Terbinafine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Major
- 2
- Moderate
- 16
Major (2)
- Terbinafine + Warfarin— CYP1A2 inhibitor that increases warfarin effect and INR; requires close INR monitoring
- Terbinafine + Warfarin Sodium— CYP1A2 inhibitor that increases warfarin effect and INR; requires close INR monitoring.
Moderate (16)
- Terbinafine + Amiodarone— Amiodarone is an inhibitor of CYP2C9 and CYP3A4 likely to substantially increase systemic exposure of terbinafine when c…
- Terbinafine + Caffeine— Terbinafine decreases caffeine clearance by 19%.
- Terbinafine + Cimetidine— Cimetidine decreases terbinafine clearance by 33%. Coadministration should be done with careful monitoring.
- Terbinafine + Clozapine— CYP2D6 or CYP3A4 inhibitor that can increase clozapine levels and lead to adverse reactions. Close monitoring and dose r…
- Terbinafine + Cyclosporine— Terbinafine increases clearance of cyclosporine by 15%. Monitor cyclosporine levels.
- Terbinafine + Desipramine— Terbinafine inhibits CYP450 2D6, resulting in 2-fold increase in Cmax and 5-fold increase in AUC of desipramine. Effects…
- Terbinafine + Dextromethorphan— Terbinafine increases dextromethorphan/dextrorphan metabolite ratio by 16- to 97-fold, converting extensive CYP2D6 metab…
- Terbinafine + Flecainide— Flecainide is predominantly metabolized by CYP450 2D6. Coadministration requires careful monitoring and may require dose…
- Terbinafine + Fluconazole— Fluconazole increases terbinafine Cmax by 52% and AUC by 69%. Inhibitor of CYP2C9 and CYP3A enzymes.
- Terbinafine + Ketoconazole— Ketoconazole is an inhibitor of CYP2C9 and CYP3A4 likely to substantially increase systemic exposure of terbinafine when…
- Terbinafine + Metoprolol— Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol, decreasing cardioselectivity.
- Terbinafine + Metoprolol Tartrate— Potent CYP2D6 inhibitor may increase metoprolol plasma concentration, decreasing cardioselectivity.
- Terbinafine + Metoprolol Tartrate And Hydrochlorothiazide— Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol; caution should be exercised.
- Terbinafine + Propafenone— Propafenone is predominantly metabolized by CYP450 2D6. Coadministration requires careful monitoring and may require dos…
- Terbinafine + Rifampin— Rifampin increases terbinafine clearance by 100%. Coadministration may require terbinafine dose adjustment.
- Terbinafine + Tamsulosin Hydrochloride— Moderate CYP2D6 inhibitor; use with caution. Effects on tamsulosin pharmacokinetics not fully evaluated.