Does Terbinafine Interact with Fluconazole?
CDI records a moderate classification for Terbinafine and Fluconazole. The stored summary is: Fluconazole increases terbinafine Cmax by 52% and AUC by 69%. Inhibitor of CYP2C9 and CYP3A enzymes. The mechanism involves cyp2c9 and cyp3a4 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Fluconazole Class
- Azole Antifungal
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP2C9 and CYP3A4 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Terbinafine and your doctor is considering prescribing Fluconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider