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Tethimide

3 interactions on record

Tethimide has 3 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Doxercalciferol. Patients taking Tethimide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Moderate: 1

Moderate (1)

Tethimide + Doxercalciferol— Enzyme inducer that may enhance the 25-hydroxylation of doxercalciferol. Dose adjustment of doxercalciferol may be neces…

Tethimide + Doxercalciferol🟡Moderate

Enzyme inducer that may enhance the 25-hydroxylation of doxercalciferol. Dose adjustment of doxercalciferol may be necessary.

Tethimide + Levothyroxine Sodiumℹ️Unknown

Drugs that alter thyroid hormone secretion Drugs that may decrease thyroid hormone secretion, which may result in hypothyroidism Aminoglutethimide Amiodarone Iodide (including iodine-containing Radiographic contrast agents) Lithium Methimazole Propylthioracil (PTU) Sulfonamides Tolbutamide Long-term lithium therapy can result in goiter in up to 50% of patients, and either subclinical or overt hypothyroidism, each in up to 20% of patients. Long-term amino-glu-tethimide therapy may minimally decrease T 4 and T 3 levels and increase TSH, although all values remain within normal limits in most patients.

Tethimide + Theophyllineℹ️Unknown

25% increase at allopurinol Amino glutethimide Increases theophylline clearance by induction of microsomal enzyme activity. 25% decrease Carbamazepine Similar to aminoglutethimide. 30% increase Phenobarbital (PB) Similar to aminoglutethimide.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.