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Does Theophylline Interact with Tethimide?

Theophylline and Tethimide have a unknown drug interaction according to U.S. FDA drug labeling data. 25% increase at allopurinol Amino glutethimide Increases theophylline clearance by induction of microsomal enzyme activity. 25% decrease Carbamazepine Similar to aminoglutethimide. 30% increase Phenobarbital (PB) Similar to aminoglutethimide. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Unknown
Theophylline Class: Methylxanthine
Management: Consult your pharmacist
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Theophylline and your doctor is considering prescribing Tethimide (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Theophylline(Theo-24)+💊 Tethimide

Severity & Interaction Details

ℹ️

unknown

Interaction documented — severity unclassified

The FDA label notes an interaction but the severity is not classified in our dataset.

Severity scale

MinorContra

On record

Yes

Drug A class

Methylxanthine

Drug B class

—

Source

FDA drug label - theophylline

What this means in plain English

25% increase at allopurinol Amino glutethimide Increases theophylline clearance by induction of microsomal enzyme activity. 25% decrease Carbamazepine Similar to aminoglutethimide. 30% increase Phenobarbital (PB) Similar to aminoglutethimide.

About Theophylline and Tethimide

Theophylline is a Methylxanthine. Theophylline is also sold under the brand name Elixophyllin. Theophylline is taken by mouth.

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

PubMed

Capture-SELEX of DNA Aptamers for Highly Selective Binding of Folate.about Theophylline · 2026-05

PubMed

Computational fluid dynamics and machine learning modeling of drug delivery by hydroxypropyl methylcellulose.about Theophylline · 2026-05

PubMed

Predicting the compressibility and compactibility profiles of pharmaceutical active ingredients for design of multi-component tablets.about Theophylline · 2026-05

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.