Hydralazine has 9 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sodium Phosphate, Dibasic, Anhydrous, Potassium Phosphate, Monobasic, And Sodium Phosphate, Monobasic, Monohydrate, Ascorbic Acid, Vitamin A Palmitate, Cholecalciferol, Thiamine Hydrochloride, Riboflavin-5 Phosphate Sodium, Pyridoxine Hydrochloride, Niacinamide, Dexpanthenol, Alpha-Tocopherol Acetate, Vitamin K1, Folic Acid, Biotin, Cyanocobalamin, Metoprolol. Patients taking Hydralazine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Major
- 1
- Moderate
- 5
- Minor
- 3
Major (1)
- Hydralazine + Sodium Phosphate, Dibasic, Anhydrous, Potassium Phosphate, Monobasic, And Sodium Phosphate, Monobasic, Monohydrate— Concurrent use with sodium phosphate may result in hypernatremia.
Moderate (5)
- Hydralazine + Ascorbic Acid, Vitamin A Palmitate, Cholecalciferol, Thiamine Hydrochloride, Riboflavin-5 Phosphate Sodium, Pyridoxine Hydrochloride, Niacinamide, Dexpanthenol, Alpha-Tocopherol Acetate, Vitamin K1, Folic Acid, Biotin, Cyanocobalamin— Concomitant administration may increase pyridoxine requirements.
- Hydralazine + Metoprolol— May inhibit presystemic metabolism of metoprolol, leading to increased concentrations of metoprolol.
- Hydralazine + Metoprolol Tartrate— May inhibit presystemic metabolism of metoprolol, leading to increased metoprolol concentrations.
- Hydralazine + Multiple Vitamins Injection— Concomitant administration may increase pyridoxine requirements.
- Hydralazine + Potassium Phosphate, Monobasic And Sodium Phosphate, Monobasic, Anhydrous— Concurrent use with sodium phosphate may result in hypernatremia.
Minor (3)
- Hydralazine + Enalapril Maleate— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.
- Hydralazine + Enalapril Maleate And Hydrochlorothiazide— Enalapril has been used concomitantly without evidence of clinically significant adverse interactions.
- Hydralazine + Pindolol— Used together without unexpected adverse interactions in clinical practice.