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Does Hydralazine Interact with Sodium Phosphate Dibasic Anhydrous Potassium Phosphate Monob?

Hydralazine and Sodium Phosphate Dibasic Anhydrous Potassium Phosphate Monob have a major drug interaction according to U.S. FDA drug labeling data. Concurrent use with sodium phosphate may result in hypernatremia. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Major
Management: Close medical supervision required
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Hydralazine and your doctor is considering prescribing Sodium Phosphate Dibasic Anhydrous Potassium Phosphate Monob (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask how frequently you should be monitored while these are co-prescribed
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Hydralazine+💊 Sodium Phosphate Dibasic Anhydrous Potassium Phosphate Monob(K Phos Neutral)

Severity & Interaction Details

⚠️

major

Use with caution — major interaction

Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

NLP:dibasic sodium phosphate, monobasic potassium phosphate and monobasic sodium phosphate

What this means in plain English

Concurrent use with sodium phosphate may result in hypernatremia.

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

FDA

FDA Safety Alert: 5% Dextrose Injection, USP 2.5 g per 50 mL (50 mg per mL) 50 mL in a 100 mL freeflex bag, Fresenius about Sodium Phosphate Dibasic Anhydrous Potassium Phosphate Monob · 2026-04

PubMed

Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of a cyclophilin A-like protein from Piriformospora indica.about Sodium Phosphate Dibasic Anhydrous Potassium Phosphate Monob · 2012-06

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.