Olanzapine And Fuoxetine has 34 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Monoamine Oxidase Inhibitors (Maois), Pimozide, Thioridazine. Patients taking Olanzapine And Fuoxetine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 34
- Contraindicated
- 3
- Major
- 2
- Moderate
- 18
Contraindicated (3)
- Olanzapine And Fuoxetine + Monoamine Oxidase Inhibitors (Maois)— MAOIs are contraindicated with olanzapine and fluoxetine combination due to risk of serious adverse effects.
- Olanzapine And Fuoxetine + Pimozide— Do not use olanzapine and fluoxetine capsules in combination with pimozide.
- Olanzapine And Fuoxetine + Thioridazine— Do not use olanzapine and fluoxetine capsules in combination with thioridazine.
Major (2)
- Olanzapine And Fuoxetine + Carbamazepine— Potential for elevated carbamazepine levels and clinical anticonvulsant toxicity.
- Olanzapine And Fuoxetine + Phenytoin— Potential for elevated phenytoin levels and clinical anticonvulsant toxicity.
Moderate (18)
- Olanzapine And Fuoxetine + Acetylsalicylic Acid— May potentiate the risk of bleeding when used with drugs that interfere with hemostasis.
- Olanzapine And Fuoxetine + Acidifying Agents— Enhanced antihypertensive effect may occur with concurrent use.
- Olanzapine And Fuoxetine + Alcohol— May potentiate sedation and orthostatic hypotension.
- Olanzapine And Fuoxetine + Clozapine— May elevate clozapine levels.
- Olanzapine And Fuoxetine + Cns-Active Drugs— Caution advised with concomitant CNS-active drugs; consider lower initial doses and conservative titration.
- Olanzapine And Fuoxetine + Dopamine Agonists— Olanzapine and fluoxetine may antagonize dopamine agonist effects.
- Olanzapine And Fuoxetine + Drugs That Prolong Qtc Interval— Use olanzapine and fluoxetine with caution with other QT-prolonging drugs.
- Olanzapine And Fuoxetine + Drugs That Prolong The Qt Interval— Use olanzapine and fluoxetine capsules with caution in combination with other QT-prolonging drugs.
- Olanzapine And Fuoxetine + Drugs Tightly Bound To Plasma Proteins— Fluoxetine may cause shifts in plasma concentrations of highly protein-bound drugs.
- Olanzapine And Fuoxetine + Fluvoxamine— May increase olanzapine levels; lower dose of olanzapine component should be considered.
- Olanzapine And Fuoxetine + Haloperidol— Elevated haloperidol levels have been observed with coadministration.
- Olanzapine And Fuoxetine + Levodopa— Olanzapine and fluoxetine may antagonize levodopa effects.
- Olanzapine And Fuoxetine + Nitrazepam— May potentiate orthostatic hypotension and sedation.
- Olanzapine And Fuoxetine + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— May potentiate the risk of bleeding when combined with olanzapine and fluoxetine.
- Olanzapine And Fuoxetine + Nsaids— May potentiate risk of bleeding when used with olanzapine and fluoxetine.
- Olanzapine And Fuoxetine + Short-Acting Antacids— Caution advised with concomitant CNS-active drugs; consider lower initial doses and conservative titration schedules.
- Olanzapine And Fuoxetine + Tcas— Monitor TCA levels during coadministration or when olanzapine and fluoxetine capsules have been recently discontinued.
- Olanzapine And Fuoxetine + Warfarin— May potentiate the risk of bleeding when used with drugs that interfere with hemostasis.