Does Olanzapine And Fuoxetine Interact with Diazepam?
Olanzapine And Fuoxetine and Diazepam have a unknown drug interaction according to U.S. FDA drug labeling data. 7.6 Potential for Other Drugs to Affect Olanzapine and Fluoxetine Capsules Benzodiazepines — Coadministration of diazepam with olanzapine potentiated the orthostatic hypotension observed with olanzapine [ see Drug Interactions ( 7.7 ) ]. Benzodiazepines — Multiple doses of olanzapine did not influence the pharmacokinetics of diazepam and its active metabolite N-desmethyldiazepam. When concurrently administered with fluoxetine, the half-life of diazepam may be prolonged in some patients [ see Clinical Pharmacology ( 12.3 ) ]. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Olanzapine And Fuoxetine Class
- Atypical Antipsychotic
- Diazepam Class
- Benzodiazepine
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Olanzapine And Fuoxetine and your doctor is considering prescribing Diazepam (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider