Leucovorin has 4 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Capecitabine, Oxaliplatin, Glucarpidase. Patients taking Leucovorin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Major
- 2
- Moderate
- 2
Major (2)
- Leucovorin + Capecitabine— Concentration of fluorouracil is increased and toxicity may be enhanced. Deaths from severe enterocolitis, diarrhea, and…
- Leucovorin + Oxaliplatin— Prolonged prothrombin time and INR occasionally associated with hemorrhage when used with oxaliplatin and anticoagulants…
Moderate (2)
- Leucovorin + Glucarpidase— GLUCARPIDASE can decrease leucovorin concentration, which may decrease the effect of leucovorin rescue unless leucovorin…
- Leucovorin + Irinotecan Hydrochloride— Co-administration with 5-FU reduces SN-38 Cmax by 14% and AUC by 8%. This sequence is recommended in combination trials.