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Meclofenamate Sodium

Also known as: Meclofenamate Sodium

Route: Oral

Check Meclofenamate Sodium Interactions →

5 interactions on record⛔ Black Box Warning

Meclofenamate Sodium has 5 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lithium, Warfarin, Acetylsalicylic Acid. Patients taking Meclofenamate Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Major: 2
Moderate: 3

Major (2)

Meclofenamate Sodium + Lithium— NSAIDs elevate plasma lithium levels and reduce renal lithium clearance by approximately 20%, increasing risk of lithium…
Meclofenamate Sodium + Warfarin— NSAIDs and warfarin have synergistic effects on GI bleeding, with combined use carrying higher risk of serious GI bleedi…

Moderate (3)

Meclofenamate Sodium + Acetylsalicylic Acid— Aspirin reduces meclofenamate sodium protein binding. Concomitant administration is not generally recommended due to pot…
Meclofenamate Sodium + Furosemide— Meclofenamate sodium can reduce the natriuretic effect of furosemide. Close monitoring for renal failure and diuretic ef…
Meclofenamate Sodium + Methotrexate— NSAIDs may competitively inhibit methotrexate accumulation and could enhance methotrexate toxicity. Caution should be us…

Meclofenamate Sodium + Lithium⚠️Major

NSAIDs elevate plasma lithium levels and reduce renal lithium clearance by approximately 20%, increasing risk of lithium toxicity. Careful monitoring is required.

Meclofenamate Sodium + Warfarin⚠️Major

NSAIDs and warfarin have synergistic effects on GI bleeding, with combined use carrying higher risk of serious GI bleeding than either drug alone.

Meclofenamate Sodium + Acetylsalicylic Acid🟡Moderate

Aspirin reduces meclofenamate sodium protein binding. Concomitant administration is not generally recommended due to potential for increased adverse effects.

Meclofenamate Sodium + Furosemide🟡Moderate

Meclofenamate sodium can reduce the natriuretic effect of furosemide. Close monitoring for renal failure and diuretic efficacy is recommended.

Meclofenamate Sodium + Methotrexate🟡Moderate

NSAIDs may competitively inhibit methotrexate accumulation and could enhance methotrexate toxicity. Caution should be used with concomitant administration.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.