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Does Lithium Interact with Meclofenamate Sodium?

Lithium and Meclofenamate Sodium have a major drug interaction according to U.S. FDA drug labeling data. NSAIDs elevate plasma lithium levels and reduce renal lithium clearance by approximately 20%, increasing risk of lithium toxicity. Careful monitoring is required. The mechanism involves inhibition of renal prostaglandin synthesis. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Lithium and Meclofenamate Sodium occurs because inhibition of renal prostaglandin synthesis. Clinically, this means nsaids elevate plasma lithium levels and reduce renal lithium clearance by approximately 20%, increasing risk of lithium toxicity. careful monitoring is required. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Lithium and your doctor is considering prescribing Meclofenamate Sodium (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Lithium(Lithium)+💊 Meclofenamate Sodium(Meclofenamate Sodium)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:meclofenamate sodium

What this means in plain English

NSAIDs elevate plasma lithium levels and reduce renal lithium clearance by approximately 20%, increasing risk of lithium toxicity. Careful monitoring is required.

What the FDA label says

"Inhibition of renal prostaglandin synthesis"

📖 Source: NLP:meclofenamate sodium

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.