Meperidine Interactions

Serious, sometimes fatal reactions have been precipitated with concomitant use. Risk of serotonin syndrome.

Source: NLP:rasagiline

Serious, sometimes fatal reactions including serotonin syndrome have been reported with concomitant use of meperidine and MAO inhibitors including selective MAO-B inhibitors.

Source: NLP:rasagiline mesylate

Serious, sometimes fatal reactions reported with concomitant use of opioid drugs and MAOIs, including selective MAO-B inhibitors.

Source: NLP:safinamide mesylate

Combination causes stupor, muscular rigidity, severe agitation, elevated temperature, severe agitation, hallucinations, and death. Typical MAOI-meperidine interaction.

Source: NLP:selegiline hydrochloride

Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.

Source: NLP:alprazolam

Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.

Source: NLP:cyclobenzaprine

Serotonin syndrome reported during combined use.

Source: NLP:cyclobenzaprine hydrochloride

Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modification; discontinue metaxalone if serotonin syndrome occurs.

Source: NLP:metaxalone

Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respiratory depression and sedation.

Source: NLP:midazolam

Concomitant use increases risk of respiratory depression and sedation. Opioids interact at mu receptors while benzodiazepines act at GABA A sites, creating additive CNS depression.

Source: NLP:midazolam hydrochloride

May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood pressure and cardiac output.

Source: NLP:propofol

Effects may be potentiated by amphetamines. Use with caution and monitor.

Source: NLP:dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, and amphetamine sulfate

Narcotic analgesic may increase certain actions or side effects of dicyclomine hydrochloride.

Source: NLP:dicyclomine hydrochloride