Meperidine has 18 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 13 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rasagiline, Rasagiline Mesylate, Safinamide Mesylate. Patients taking Meperidine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Contraindicated
- 4
- Major
- 13
- Moderate
- 1
Contraindicated (4)
- Meperidine + Rasagiline— Serious, sometimes fatal reactions have been precipitated with concomitant use. Risk of serotonin syndrome.
- Meperidine + Rasagiline Mesylate— Serious, sometimes fatal reactions including serotonin syndrome have been reported with concomitant use of meperidine an…
- Meperidine + Safinamide Mesylate— Serious, sometimes fatal reactions reported with concomitant use of opioid drugs and MAOIs, including selective MAO-B in…
- Meperidine + Selegiline Hydrochloride— Combination causes stupor, muscular rigidity, severe agitation, elevated temperature, severe agitation, hallucinations, …
Major (13)
- Meperidine + Alprazolam— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.
- Meperidine + Alprazolam C-Iv— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Meperidine + Cyclobenzaprine— Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
- Meperidine + Cyclobenzaprine Hcl Er— Postmarketing cases of serotonin syndrome reported during combined use with meperidine.
- Meperidine + Cyclobenzaprine Hydrochloride— Serotonin syndrome reported during combined use.
- Meperidine + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— Opioid whose effects may be potentiated by amphetamines, with serotonergic properties increasing serotonin syndrome risk…
- Meperidine + Metaxalone— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Meperidine + Midazolam— Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respirator…
- Meperidine + Midazolam Hydrochloride— Concomitant use increases risk of respiratory depression and sedation. Opioids interact at mu receptors while benzodiaze…
- Meperidine + Midazolam In 0.8% Sodium Chloride— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites. Sedative effect…
- Meperidine + Midazolam Injection, 10 Mg— Concomitant use increases risk of respiratory depression and accentuates sedative effect. Monitor closely for respirator…
- Meperidine + Propofol— May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood p…
- Meperidine + Propofol Injectable Emulsion— May reduce induction dose requirements and increase anesthetic/sedative effects with pronounced decreases in systolic, d…
Moderate (1)
- Meperidine + Dicyclomine Hydrochloride— Narcotic analgesic may increase certain actions or side effects of dicyclomine hydrochloride.