Home›Rasagiline Mesylate›Rasagiline Mesylate + Meperidine

Does Rasagiline Mesylate Interact with Meperidine?

Rasagiline Mesylate and Meperidine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Serious, sometimes fatal reactions including serotonin syndrome have been reported with concomitant use of meperidine and MAO inhibitors including selective MAO-B inhibitors. The mechanism involves mao inhibition leading to serotonin syndrome. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Rasagiline Mesylate and Meperidine occurs because mao inhibition leading to serotonin syndrome. Clinically, this means serious, sometimes fatal reactions including serotonin syndrome have been reported with concomitant use of meperidine and mao inhibitors including selective mao-b inhibitors. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Rasagiline Mesylate and your doctor is considering prescribing Meperidine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Rasagiline Mesylate(Rasagiline Mesylate)+💊 Meperidine

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:rasagiline mesylate

What this means in plain English

Serious, sometimes fatal reactions including serotonin syndrome have been reported with concomitant use of meperidine and MAO inhibitors including selective MAO-B inhibitors.

What the FDA label says

"MAO inhibition leading to serotonin syndrome"

📖 Source: NLP:rasagiline mesylate

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Rasagiline Mesylate and Meperidine against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.