Naltrexone has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Bremelanotide, Antidiabetic Medicines, Cough And Cold Remedies. Patients taking Naltrexone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 1
- Major
- 4
- Moderate
- 3
- Minor
- 2
Contraindicated (1)
- Naltrexone + Bremelanotide— VYLEESI may significantly decrease systemic exposure of orally-administered naltrexone; avoid use with orally administer…
Major (4)
- Naltrexone + Antidiabetic Medicines— Naltrexone antagonizes the effects of opioid-containing medicines, including cough and cold remedies, antidiarrheal prep…
- Naltrexone + Cough And Cold Remedies— Naltrexone antagonizes the effects of opioid-containing cough and cold remedies.
- Naltrexone + Iron-Containing Preparations— Naltrexone antagonizes the effects of opioid-containing antidiarrheal preparations.
- Naltrexone + Opioid Analgesics— Naltrexone antagonizes the effects of opioid analgesics, preventing their therapeutic benefit.
Moderate (3)
- Naltrexone + Lofexidine— Coadministration may reduce efficacy of oral naltrexone if taken within 2 hours of lofexidine due to altered pharmacokin…
- Naltrexone + Lofexidine Hydrochloride— Concomitant use may reduce efficacy of oral naltrexone, particularly if administered within 2 hours of lofexidine. Non-o…
- Naltrexone + Nabilone— Oral THC effects were enhanced by opioid receptor blockade.
Minor (2)
- Naltrexone + Acamprosate Calcium— Clinically important interactions between naltrexone and acamprosate were not observed.
- Naltrexone + Acamprosate Calcium Enteric-Coated— Clinically important interactions between naltrexone and acamprosate were not observed.