Naltrexone + Lofexidine Hydrochloride Interaction
Moderateinteraction on record
Description
Concomitant use may reduce efficacy of oral naltrexone, particularly if administered within 2 hours of lofexidine. Non-oral routes are not expected to have this interaction.
Mechanism
Altered steady-state pharmacokinetics of naltrexone
Source: NLP:lofexidine hydrochloride