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Does Naltrexone Interact with Bremelanotide?

Naltrexone and Bremelanotide have a contraindicated drug interaction according to U.S. FDA drug labeling data. VYLEESI may significantly decrease systemic exposure of orally-administered naltrexone; avoid use with orally administered naltrexone-containing products intended to treat alcohol or opioid addiction due to severe consequence of treatment failure. The mechanism involves vyleesi slows gastric emptying, reducing absorption of orally-administered naltrexone. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Naltrexone and Bremelanotide occurs because vyleesi slows gastric emptying, reducing absorption of orally-administered naltrexone. Clinically, this means vyleesi may significantly decrease systemic exposure of orally-administered naltrexone; avoid use with orally administered naltrexone-containing products intended to treat alcohol or opioid addiction due to severe consequence of treatment failure. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Naltrexone and your doctor is considering prescribing Bremelanotide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Naltrexone(Vivitrol)+💊 Bremelanotide(Vyleesi)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:bremelanotide

What this means in plain English

VYLEESI may significantly decrease systemic exposure of orally-administered naltrexone; avoid use with orally administered naltrexone-containing products intended to treat alcohol or opioid addiction due to severe consequence of treatment failure.

What the FDA label says

"VYLEESI slows gastric emptying, reducing absorption of orally-administered naltrexone"

📖 Source: NLP:bremelanotide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.