Paricalcitol has 24 known drug interactions based on U.S. FDA drug labeling data. 18 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Andthiazide, Calcium Antagonists, Clarithromycin. Patients taking Paricalcitol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 24
- Major
- 18
- Moderate
- 5
Major (18)
- Paricalcitol + Andthiazide— Thiazide diuretics induce hypercalcemia by reducing urinary calcium excretion. Monitor calcium frequently and adjust par…
- Paricalcitol + Calcium Antagonists— Concomitant administration of high doses may increase risk of hypercalcemia. Monitor calcium frequently and adjust paric…
- Paricalcitol + Clarithromycin— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Conivaptan— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Digitalis Glycosides— Paricalcitol-induced hypercalcemia can potentiate digitalis toxicity risk. Monitor for digitalis toxicity signs and incr…
- Paricalcitol + Grapefruit Juice— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Indinavir— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Itraconazole— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Ketoconazole— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Lopinavir And Ritonavir— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Mibefradil— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Nefazodone— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Nelfinavir— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Posaconazole— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Ritonavir— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Saquinavir— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
- Paricalcitol + Vitamin D— Concomitant administration of high doses may increase risk of hypercalcemia. Monitor calcium frequently and adjust paric…
- Paricalcitol + Voriconazole— Strong CYP3A inhibitor increases paricalcitol exposure. Dose adjustment may be necessary; monitor intact PTH and serum c…
Moderate (5)
- Paricalcitol + Boceprevir— Strong CYP3A inhibitor that increases paricalcitol exposure. Dose adjustment may be necessary; monitor iPTH and serum ca…
- Paricalcitol + Cholestyramine Light— Impairs intestinal absorption of fat-soluble vitamins and may reduce paricalcitol absorption. Separate dosing by at leas…
- Paricalcitol + Multivitamin/Mineral— May affect fat absorption and reduce paricalcitol absorption. Separate dosing by at least 1 hour before or 4-6 hours aft…
- Paricalcitol + Telaprevir— Strong CYP3A inhibitor that increases paricalcitol exposure. Dose adjustment may be necessary; monitor iPTH and serum ca…
- Paricalcitol + Telithromycin— Strong CYP3A inhibitor that increases paricalcitol exposure. Dose adjustment may be necessary; monitor iPTH and serum ca…