Norepinephrine has 31 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Esmolol Hydrochloride, Sodium Bicarbonate, Sodium Bicarbonate Injection,. Patients taking Norepinephrine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 31
- Contraindicated
- 3
- Major
- 12
- Moderate
- 15
- Minor
- 1
Contraindicated (3)
- Norepinephrine + Esmolol Hydrochloride— Do not use esmolol to control tachycardia in patients receiving norepinephrine due to risk of reducing cardiac contracti…
- Norepinephrine + Sodium Bicarbonate— Incompatible with sodium bicarbonate solution; do not combine.
- Norepinephrine + Sodium Bicarbonate Injection,— Norepinephrine is incompatible with sodium bicarbonate solution and should not be admixed.
Major (12)
- Norepinephrine + Carbidopa, Levodopa And Entacapone— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
- Norepinephrine + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— Effects may be potentiated by amphetamines.
- Norepinephrine + Dopamine Hydrochloride— Concomitant use may result in severe hypertension.
- Norepinephrine + Droxidopa— Concomitant use may increase risk for supine hypertension due to additive blood pressure-raising effects.
- Norepinephrine + Lidocaine Hydrochloride— Administration of lidocaine with norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepr…
- Norepinephrine + Liothyronine Sodium— Thyroid hormones increase adrenergic effect of catecholamines. May increase risk of precipitating coronary insufficiency…
- Norepinephrine + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Administration to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolo…
- Norepinephrine + Mepivacaine Hydrochloride— Local anesthetic solutions containing Norepinephrine may produce severe, prolonged hypertension in patients receiving tr…
- Norepinephrine + Milnacipran Hydrochloride— Concomitant use may be associated with paroxysmal hypertension and possible arrhythmia due to norepinephrine reuptake in…
- Norepinephrine + Phenylephrine Hydrochloride— Agonistic effects increase phenylephrine blood pressure effect.
- Norepinephrine + Promethazine, Phenylephrine, Codeine— Concomitant use may enhance the pressor response and increase the risk of hypertension.
- Norepinephrine + Triamcinolone Acetonide— Severe, prolonged hypertension may occur with local anesthetic solutions containing norepinephrine in patients receiving…
Moderate (15)
- Norepinephrine + Atenolol And Chlorthalidone— Thiazides may decrease arterial responsiveness to norepinephrine, though this does not preclude therapeutic effectivenes…
- Norepinephrine + Chlorothiazide— Possible decreased response to norepinephrine may occur, but not sufficient to preclude its use with chlorothiazide.
- Norepinephrine + Chlorothiazide Sodium— Possible decreased response to norepinephrine when used concurrently with chlorothiazide sodium, but not sufficient to p…
- Norepinephrine + Chlorthalidone— Chlorthalidone may decrease arterial responsiveness to norepinephrine, though this does not preclude its therapeutic eff…
- Norepinephrine + Furosemide— Furosemide may decrease arterial responsiveness to norepinephrine's vasoconstricting effect.
- Norepinephrine + Furosemide Injection 80 Mg/ 10 Ml— Furosemide may decrease arterial responsiveness to norepinephrine. Monitor blood pressure or mean arterial pressure.
- Norepinephrine + Furosemide, Benzalkonium Chloride— Furosemide may decrease arterial responsiveness to norepinephrine, though norepinephrine may still be used effectively.
- Norepinephrine + Hydrochlorothiazide— Possible decreased response to pressor amines but not sufficient to preclude their use.
- Norepinephrine + Indapamide— Indapamide may decrease arterial responsiveness to norepinephrine, though diminution is not sufficient to preclude thera…
- Norepinephrine + Irbesartan And Hydrochlorothiazide— Possible decreased response to pressor amines but not sufficient to preclude their use.
- Norepinephrine + Metolazone— Metolazone may decrease arterial responsiveness to norepinephrine, though not sufficient to preclude therapeutic effecti…
- Norepinephrine + Metoprolol Tartrate And Hydrochlorothiazide— Thiazides may decrease arterial responsiveness to norepinephrine, but not enough to preclude its therapeutic effectivene…
- Norepinephrine + Spironolactone— Spironolactone reduces vascular responsiveness to norepinephrine; caution needed during anesthesia.
- Norepinephrine + Spironolactone And Hydrochlorothiazide— Both spironolactone and hydrochlorothiazide reduce vascular responsiveness to norepinephrine; caution during anesthesia.
- Norepinephrine + Triamterene And Hydrochlorothiazide— Thiazides may decrease arterial responsiveness to norepinephrine, though diminution not sufficient to preclude therapeut…
Minor (1)
- Norepinephrine + Amiloride Hydrochloride And Hydrochlorothiazide— Possible decreased response to pressor amines but not sufficient to preclude their use.