Pentazocine has 11 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alprazolam, Alprazolam C-Iv, Atropa Belladonna And Opium. Patients taking Pentazocine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Major
- 7
- Moderate
- 4
Major (7)
- Pentazocine + Alprazolam— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.
- Pentazocine + Alprazolam C-Iv— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Pentazocine + Atropa Belladonna And Opium— Mixed agonist/antagonist opioid may reduce analgesic effect and/or precipitate withdrawal symptoms. Avoid concomitant us…
- Pentazocine + Hydrocodone Bitartrate And Acetaminophen— Mixed agonist/antagonist analgesic may precipitate withdrawal in opioid-dependent patients.
- Pentazocine + Hydromorphone Hydrochloride— May reduce analgesic effect of hydromorphone and/or precipitate withdrawal symptoms. Avoid concomitant use.
- Pentazocine + Levorphanol Tartrate— Mixed agonist/antagonist opioid may reduce analgesic effect of levorphanol and precipitate withdrawal symptoms. Advise p…
- Pentazocine + Morphine Sulfate— Mixed agonist/antagonist opioid may reduce analgesic effect and/or precipitate withdrawal symptoms. Avoid concomitant us…
Moderate (4)
- Pentazocine + Acetaminophen, Caffeine, Dihydrocodeine Bitartrate— Mixed agonist/antagonist opioid may reduce the analgesic effect of this combination product.
- Pentazocine + Nicotine— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
- Pentazocine + Oxycodone Hydrochloride— Mixed agonist/antagonist may reduce analgesic effect and/or precipitate withdrawal symptoms in opioid-dependent patients…
- Pentazocine + Remifentanil Hydrochloride— Mixed agonist/antagonist may reduce analgesic effect of remifentanil and/or precipitate withdrawal symptoms.