Pentostatin has 8 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Fludarabine Phosphate, Nelarabine, Carmustine. Patients taking Pentostatin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Contraindicated
- 2
- Major
- 4
- Moderate
- 2
Contraindicated (2)
- Pentostatin + Fludarabine Phosphate— Combined use not recommended due to increased risk of fatal pulmonary toxicity.
- Pentostatin + Nelarabine— Administration of nelarabine in combination with pentostatin (an adenosine deaminase inhibitor) is not recommended.
Major (4)
- Pentostatin + Carmustine— Acute pulmonary edema and hypotension leading to death reported when used with pentostatin in combination chemotherapy r…
- Pentostatin + Cyclophosphamide— Increased cardiotoxicity may result from combined effect with cyclophosphamide.
- Pentostatin + Cyclophosphamide Injection, Solution— Pentostatin potentiates cyclophosphamide's cardiotoxicity when used concomitantly or sequentially.
- Pentostatin + Etoposide— Acute pulmonary edema and hypotension leading to death reported when used with pentostatin in combination chemotherapy r…
Moderate (2)
- Pentostatin + Allopurinol— Both drugs associated with skin rashes. Combined use did not increase rash incidence in clinical studies, but one report…
- Pentostatin + Vidarabine— Pentostatin enhances effects of vidarabine, may result in increased adverse reactions. Therapeutic benefit not establish…