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Does Pentostatin Interact with Fludarabine Phosphate?

Pentostatin and Fludarabine Phosphate have a contraindicated drug interaction according to U.S. FDA drug labeling data. Combined use not recommended due to increased risk of fatal pulmonary toxicity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Pentostatin Class
Nucleoside Metabolic Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Pentostatin and your doctor is considering prescribing Fludarabine Phosphate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Pentostatin(Nipent)+💊 Fludarabine Phosphate(Fludarabine Phosphate)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Nucleoside Metabolic Inhibitor
Drug B class
—
Source
NLP:pentostatin

What this means in plain English

Combined use not recommended due to increased risk of fatal pulmonary toxicity.

About Pentostatin and Fludarabine Phosphate

Pentostatin is a Nucleoside Metabolic Inhibitor. Pentostatin is also sold under the brand name Nipent. Both medications are given by intravenous (IV) infusion. Both Pentostatin and Fludarabine Phosphate carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.