Phenylephrine Hci has 17 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 11 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cocaine Hydrochloride, Tranylcypromine Sulfate, Adrenergic Blockers. Patients taking Phenylephrine Hci should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 17
- Contraindicated
- 2
- Major
- 11
- Moderate
- 4
Contraindicated (2)
- Phenylephrine Hci + Cocaine Hydrochloride— Reports of myocardial ischemia, myocardial infarction, and ventricular arrhythmias with concomitant use during nasal sur…
- Phenylephrine Hci + Tranylcypromine Sulfate— Sympathomimetic vasopressor contraindicated; avoid or emergency use only with tranylcypromine discontinuation and monito…
Major (11)
- Phenylephrine Hci + Adrenergic Blockers— Increase the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hci + Atomoxetine— Norepinephrine transport inhibitor that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hci + Atropine Sulfate— Increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hci + Clonidine— α-2 adrenergic agonist that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hci + Cocaine Hydrochloride Nasal— Reports of myocardial ischemia, myocardial infarction, and ventricular arrhythmias with concomitant use during nasal sur…
- Phenylephrine Hci + Guanfacine— Centrally-acting sympatholytic agent that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hci + Methylergonovine Maleate— Ergot alkaloid that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hci + Midodrine Hydrochloride— Increases risk of hypertension when used concomitantly with midodrine. Avoid concomitant use or monitor blood pressure c…
- Phenylephrine Hci + Reserpine— Centrally-acting sympatholytic agent that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hci + Selegiline— Monoamine oxidase inhibitor that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hci + Topical Steroids— Increase the pressor effect of phenylephrine hydrochloride.
Moderate (4)
- Phenylephrine Hci + Amiodarone— α-adrenergic blocking agent that blocks phenylephrine and is blocked by phenylephrine.
- Phenylephrine Hci + Chlorpromazine— Phenothiazine α-adrenergic blocking agent that blocks phenylephrine and is blocked by phenylephrine.
- Phenylephrine Hci + Iobenguane I-123— Sympathomimetic amine that may decrease norepinephrine uptake and cause false negative imaging results with iobenguane.
- Phenylephrine Hci + Nicotine— Smoking cessation with nicotine replacement may require dose increase due to decreased circulating catecholamines.