Prazosin has 39 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aripiprazole Lauroxil, Midodrine Hydrochloride, Propranolol Hydrochloride. Patients taking Prazosin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 39
- Major
- 3
- Moderate
- 9
- Minor
- 21
Major (3)
- Prazosin + Aripiprazole Lauroxil— Antihypertensive drug whose effect may be enhanced by aripiprazole's alpha adrenergic antagonism. Avoid concomitant use.
- Prazosin + Midodrine Hydrochloride— Alpha-adrenergic blocking agent can antagonize the effects of midodrine hydrochloride.
- Prazosin + Propranolol Hydrochloride— Co-administration of propranolol with alpha-blocker prazosin has been associated with prolongation of first dose hypoten…
Moderate (9)
- Prazosin + Acidifying Agents— Addition of other antihypertensive agents to prazosin causes additive hypotensive effect; introduce cautiously and retit…
- Prazosin + Diuretics— Addition of a diuretic to prazosin causes additive hypotensive effect; dose reduction and careful titration recommended.
- Prazosin + Mao Inhibitors— Concomitant administration with PDE-5 inhibitors results in additive blood pressure lowering effects and symptomatic hyp…
- Prazosin + Metoprolol— Beta-adrenergic blockers may potentiate postural hypotensive effect of first dose of prazosin, probably by preventing re…
- Prazosin + Metoprolol Tartrate— Beta-blocker may potentiate postural hypotensive effect of first dose by preventing reflex tachycardia.
- Prazosin + Nicotine— Smoking cessation with nicotine replacement may require dose decrease due to decreased circulating catecholamines.
- Prazosin + Propranolol— Prazosin has been administered with propranolol in limited clinical experience; caution noted in WARNINGS section.
- Prazosin + Stiripentol— DIACOMIT may inhibit BCRP transport of prazosin; consider dose reduction if adverse reactions occur.
- Prazosin + Verapamil Hydrochloride— Concomitant administration of verapamil and prazosin resulted in exaggerated hypotensive response in one study.
Minor (21)
- Prazosin + Allopurinol— Prazosin has been administered without adverse drug interaction with allopurinol in limited clinical experience.
- Prazosin + Aspirin— Prazosin has been administered without adverse drug interaction with aspirin in limited clinical experience.
- Prazosin + Chlordiazepoxide— Prazosin has been administered without adverse drug interaction with chlordiazepoxide in limited clinical experience.
- Prazosin + Chlorpropamide— Prazosin has been administered without adverse drug interaction with chlorpropamide in limited clinical experience.
- Prazosin + Colchicine— Prazosin has been administered without adverse drug interaction with colchicine in limited clinical experience.
- Prazosin + Diazepam— Prazosin has been administered without adverse drug interaction with diazepam in limited clinical experience.
- Prazosin + Digitalis Glycosides— Prazosin has been administered without adverse drug interaction with digitalis in limited clinical experience.
- Prazosin + Digoxin— Prazosin has been administered without adverse drug interaction with digoxin in limited clinical experience.
- Prazosin + Enalapril Maleate— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.
- Prazosin + Enalapril Maleate And Hydrochlorothiazide— Enalapril has been used concomitantly without evidence of clinically significant adverse interactions.
- Prazosin + Indomethacin— Prazosin has been administered without adverse drug interaction with indomethacin in limited clinical experience.
- Prazosin + Insulin Human— Prazosin has been administered without adverse drug interaction with insulin in limited clinical experience.
- Prazosin + Phenformin— Prazosin has been administered without adverse drug interaction with phenformin in limited clinical experience.
- Prazosin + Phenobarbital— Prazosin has been administered without adverse drug interaction with phenobarbital in limited clinical experience.
- Prazosin + Phenylbutazone— Prazosin has been administered without adverse drug interaction with phenylbutazone in limited clinical experience.
- Prazosin + Probenecid— Prazosin has been administered without adverse drug interaction with probenecid in limited clinical experience.
- Prazosin + Procainamide— Prazosin has been administered without adverse drug interaction with procainamide in limited clinical experience.
- Prazosin + Propoxyphene— Prazosin has been administered without adverse drug interaction with propoxyphene in limited clinical experience.
- Prazosin + Quinidine— Prazosin has been administered without adverse drug interaction with quinidine in limited clinical experience.
- Prazosin + Tolazamide— Prazosin has been administered without adverse drug interaction with tolazamide in limited clinical experience.
- Prazosin + Tolbutamide— Prazosin has been administered without adverse drug interaction with tolbutamide in limited clinical experience.