Does Prazosin Interact with Midodrine Hydrochloride?
The midodrine hydrochloride label names prazosin among alpha-adrenergic blocking agents that can oppose midodrine’s effects.
Label evidence and limitations
Named-drug label evidence. The label supports antagonism of effect. It does not assign CDI’s major category or establish how either medicine should be changed for an individual patient.
Product scope: Oral midodrine hydrochloride tablets.
Read the DailyMed label: Midodrine Hydrochloride Tablets, USP Rx only
Section: Drug Interactions. Compared version 13, label date 2026-08-20. The linked label may be updated after this comparison.
The original record has no saved label identifier. This comparison uses a label located during the source check; it does not recover the original extraction source.
AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.
- Stored CDI classification
- Major
- Management
- Confirm exact products with your pharmacist
- Data Source
- Product label via NLM DailyMed
What To Tell Your Doctor or Pharmacist
If you are taking Prazosin and your doctor is considering prescribing Midodrine Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider