Promethazine

3 interactions on record

Promethazine has 3 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Haloperidol Decanoate, Haloperidol Lactate, Zaleplon. Patients taking Promethazine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Moderate: 3

Moderate (3)

Promethazine + Haloperidol Decanoate— CYP2D6 inhibitor that increases haloperidol plasma concentrations; monitor for increased adverse effects including QTc p…
Promethazine + Haloperidol Lactate— CYP2D6 inhibitor that increases haloperidol plasma concentrations, raising risk of adverse events including QTc prolonga…
Promethazine + Zaleplon— Co-administration resulted in 15% decrease in maximal zaleplon plasma concentrations with no change in AUC. Pharmacodyna…

Promethazine + Haloperidol Decanoate🟡Moderate

CYP2D6 inhibitor that increases haloperidol plasma concentrations; monitor for increased adverse effects including QTc prolongation.

Promethazine + Haloperidol Lactate🟡Moderate

CYP2D6 inhibitor that increases haloperidol plasma concentrations, raising risk of adverse events including QTc prolongation.

Promethazine + Zaleplon🟡Moderate

Co-administration resulted in 15% decrease in maximal zaleplon plasma concentrations with no change in AUC. Pharmacodynamics not evaluated; caution advised.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.