Does Zaleplon Interact with Promethazine?
CDI records a moderate classification for Zaleplon and Promethazine. The stored summary is: Co-administration resulted in 15% decrease in maximal zaleplon plasma concentrations with no change in AUC. Pharmacodynamics not evaluated; caution advised. The mechanism involves potential pharmacodynamic interaction; pharmacokinetic changes of minor significance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Zaleplon Class
- gamma-Aminobutyric Acid A Receptor Agonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Potential pharmacodynamic interaction; pharmacokinetic changes of minor significance
What To Tell Your Doctor or Pharmacist
If you are taking Zaleplon and your doctor is considering prescribing Promethazine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider