Quinine Sulfate has 25 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Class Ia Antiarrhythmics, Class Iii Antiarrhythmics, Erythromycin. Patients taking Quinine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 25
- Contraindicated
- 8
- Major
- 1
- Moderate
- 10
Contraindicated (8)
- Quinine Sulfate + Class Ia Antiarrhythmics— Quinine sulfate prolongs QT interval; concomitant use may cause ECG abnormalities including QT prolongation and Torsades…
- Quinine Sulfate + Class Iii Antiarrhythmics— Quinine sulfate prolongs QT interval; concomitant use may cause ECG abnormalities including QT prolongation and Torsades…
- Quinine Sulfate + Erythromycin— CYP3A4 inhibitor causing increased quinine plasma levels. Concomitant administration should be avoided.
- Quinine Sulfate + Halofantrine— Other antimalarial causing ECG abnormalities including QT prolongation when combined with quinine sulfate.
- Quinine Sulfate + Mefloquine— Other antimalarial causing ECG abnormalities including QT prolongation when combined with quinine sulfate.
- Quinine Sulfate + Rifampin— CYP3A4 inducer causing decreased quinine plasma levels. Concomitant administration should be avoided.
- Quinine Sulfate + Ritonavir— Increased quinine plasma levels have been observed when used concomitantly. Concomitant administration should be avoided…
- Quinine Sulfate + Troleandomycin— CYP3A4 inhibitor causing increased quinine plasma levels. Concomitant administration should be avoided.
Major (1)
- Quinine Sulfate + Digoxin— Quinine inhibits CYP3A4 and increases digoxin plasma concentration, potentially leading to toxicity.
Moderate (10)
- Quinine Sulfate + Aluminum & Magnesium Hydroxides— Antacids containing aluminum and/or magnesium may delay or decrease absorption of quinine. Concomitant administration sh…
- Quinine Sulfate + Aminophylline— No change in quinine dosage necessary with concomitant use. Patients should be monitored closely for adverse reactions a…
- Quinine Sulfate + Carbamazepine— CYP3A4 inducer that may decrease quinine plasma concentrations and reduce efficacy.
- Quinine Sulfate + Cimetidine— Nonspecific CYP450 inhibitor. Ranitidine is preferred over cimetidine when concomitant use is necessary. Patients should…
- Quinine Sulfate + Ketoconazole— CYP3A4 inhibitor. No change in quinine dosage necessary, but patients should be monitored closely for adverse reactions …
- Quinine Sulfate + Phenobarbital— CYP3A4 inducer that may decrease quinine plasma concentrations and reduce efficacy.
- Quinine Sulfate + Phenytoin— CYP3A4 inducer that may decrease quinine plasma concentrations and reduce efficacy.
- Quinine Sulfate + Ranitidine— Nonspecific CYP450 inhibitor. Preferred over cimetidine when concomitant use is necessary. Patients should be monitored …
- Quinine Sulfate + Tetracycline— May be concomitantly administered with quinine sulfate capsules. Patients should be monitored closely for adverse reacti…
- Quinine Sulfate + Theophylline— No change in quinine dosage necessary with concomitant use. Patients should be monitored closely for adverse reactions a…