Does Ritonavir Interact with Quinine Sulfate?
CDI records a contraindicated classification for Ritonavir and Quinine Sulfate. The stored summary is: Increased quinine plasma levels have been observed when used concomitantly. Concomitant administration should be avoided. The mechanism involves increased quinine plasma concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Ritonavir Class
- Cytochrome P450 3A Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased quinine plasma concentrations
What To Tell Your Doctor or Pharmacist
If you are taking Ritonavir and your doctor is considering prescribing Quinine Sulfate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider