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Reserpine

67 interactions on record

Reserpine has 67 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 32 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbidopa And Levodopa, Deutetrabenazine, Tetrabenazine. Patients taking Reserpine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 67
Contraindicated: 3
Major: 32
Moderate: 32

Contraindicated (3)

Reserpine + Carbidopa And Levodopa— Use with carbidopa and levodopa is not recommended due to dopamine-depleting effects that may counteract the therapeutic…
Reserpine + Deutetrabenazine— Contraindicated; concomitant use risks major depletion of serotonin and norepinephrine. At least 20 days must elapse aft…
Reserpine + Tetrabenazine— Should not be used concomitantly. Must wait at least 20 days after stopping reserpine before starting tetrabenazine to a…

Major (32)

Reserpine + Acebutolol Hydrochloride— Additive effect may cause marked bradycardia or hypotension presenting as vertigo, syncope, or orthostatic changes in bl…
Reserpine + Atenolol— Additive effect may cause hypotension and marked bradycardia, potentially producing vertigo, syncope, or postural hypote…
Reserpine + Atenolol And Chlorthalidone— Catecholamine depletor may cause severe hypotension and marked bradycardia with vertigo, syncope, or postural hypotensio…
Reserpine + Betaxolol— Catecholamine-depleting drugs may have additive effect with beta-blockers, causing hypotension, marked bradycardia, vert…
Reserpine + Betaxolol Hydrochloride— Catecholamine-depleting drug may have additive effects with beta-blockade, potentially causing hypotension, bradycardia,…
Reserpine + Bisoprolol Fumarate— Catecholamine-depleting drug that may produce excessive reduction of sympathetic activity when combined with bisoprolol …
Reserpine + Bisoprolol Fumarate And Hydrochlorothiazide— Catecholamine-depleting drug that with bisoprolol's beta-adrenergic blocking action may produce excessive reduction of s…
Reserpine + Brimonidine Tartrate And Timolol Maleate— Catecholamine-depleting drug may produce additive effects causing hypotension and/or marked bradycardia, with risk of ve…
Reserpine + Carteolol Hydrochloride— Possible additive effects producing hypotension and/or marked bradycardia, which may result in vertigo, syncope, or post…
Reserpine + Carvedilol— Hypotensive agent that may increase risk of hypotension and/or severe bradycardia when combined with carvedilol.
Reserpine + Carvedilol Phosphate— Catecholamine-depleting agent that may increase risk of hypotension and severe bradycardia when combined with carvedilol…
Reserpine + Cladribine— Potent BCRP, ENT1, and CNT3 transporter inhibitor may alter cladribine bioavailability, intracellular distribution, and …
Reserpine + Dorzolamide Hydrochloride And Timolol Maleate Ophthalmic Solution— Catecholamine-depleting drug with additive effects producing hypotension and/or marked bradycardia, which may result in …
Reserpine + Dorzolamide Hydrochloride And Timolol Maleate Preservative Free— Catecholamine-depleting drug with additive effects; may produce hypotension and/or marked bradycardia, leading to vertig…
Reserpine + Metoprolol— Catecholamine-depleting drug with additive effect on metoprolol causing hypotension or marked bradycardia, potentially p…
Reserpine + Metoprolol Succinate— Catecholamine-depleting drug may have additive effect with metoprolol, causing hypotension, marked bradycardia, vertigo,…
Reserpine + Metoprolol Succinate Er— Catecholamine depleting drug with additive effect when given with metoprolol succinate ER, may cause hypotension or mark…
Reserpine + Metoprolol Tartrate— Catecholamine-depleting drug with additive effect; may cause hypotension, marked bradycardia, vertigo, syncope, or postu…
Reserpine + Metoprolol Tartrate And Hydrochlorothiazide— Catecholamine-depleting drug that may have additive effect with metoprolol, increasing risk of hypotension or bradycardi…
Reserpine + Nadolol— Additive effect with nadolol; monitor closely for hypotension and/or excessive bradycardia (vertigo, syncope, postural h…
Reserpine + Nebivolol— Catecholamine-depleting drug; concomitant use may produce excessive reduction of sympathetic activity. Closely monitor p…
Reserpine + Nebivolol Hydrochloride— Catecholamine-depleting drug may produce excessive reduction of sympathetic activity when combined with nebivolol's β-bl…
Reserpine + Phenylephrine Hci— Centrally-acting sympatholytic agent that increases the pressor effect of phenylephrine hydrochloride.
Reserpine + Phenylephrine Hydrochloride— Centrally-acting sympatholytic agent that increases the pressor effect of phenylephrine hydrochloride.
Reserpine + Phenylephrine Hydrochloride Injection, Solution— Centrally-acting sympatholytic agent increases pressor effect of phenylephrine hydrochloride.
Reserpine + Pindolol— Additive hypotensive and bradycardic effects; may produce vertigo, syncope, or postural hypotension. Close observation r…
Reserpine + Propranolol Hydrochloride— Catecholamine-depleting effect may cause excessive reduction of sympathetic activity resulting in hypotension, bradycard…
Reserpine + Sotalol Hydrochloride— Catecholamine-depleting agent; may produce excessive reduction of resting sympathetic nervous tone, causing hypotension …
Reserpine + Timolol— Additive effects with beta-blocker may produce hypotension and/or marked bradycardia, leading to vertigo, syncope, or po…
Reserpine + Timolol Hemihydrate— Catecholamine-depleting drug with potential additive effects producing hypotension and/or marked bradycardia, which may …
Reserpine + Timolol Maleate— Close observation recommended when timolol is administered with reserpine due to possible additive effects and productio…
Reserpine + Timolol Maleate Ophthalmic Gel Forming Solution 0.25%— Close observation recommended due to possible additive effects and production of hypotension and/or marked bradycardia, …

Moderate (32)

Reserpine + Amphetamine— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels, reducing efficacy.
Reserpine + Amphetamine Sulfate— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
Reserpine + Desloratadine And Pseudoephedrine Sulfate— Pseudoephedrine may reduce the antihypertensive effects of reserpine. Exercise caution when used concomitantly.
Reserpine + Dextroamphetamine— Gastrointestinal acidifying agent lowers amphetamine absorption and blood levels, reducing efficacy.
Reserpine + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— Acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on clinical …
Reserpine + Dextroamphetamine Sulfate— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
Reserpine + Ephedrine Sulfate— Antagonizes pressor effect of ephedrine. Carefully monitor blood pressure.
Reserpine + Fosphenytoin Sodium— May decrease phenytoin serum levels; dose adjustment may be required.
Reserpine + Glimepiride— May lead to either potentiation or weakening of glimepiride's glucose-lowering effect.
Reserpine + Glipizide— May lead to either potentiation or weakening of glucose-lowering effect; may mask hypoglycemia signs.
Reserpine + Insulin Aspart Injection— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring required.
Reserpine + Insulin Aspart-Szjj— May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.
Reserpine + Insulin Degludec— May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.
Reserpine + Insulin Degludec And Liraglutide— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.
Reserpine + Insulin Detemir— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.
Reserpine + Insulin Glargine— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.
Reserpine + Insulin Glargine And Lixisenatide— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.
Reserpine + Insulin Glargine-Aglr— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.
Reserpine + Insulin Glargine-Yfgn— May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.
Reserpine + Insulin Glulisine— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.
Reserpine + Insulin Human— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring required.
Reserpine + Insulin Icodec-Abae— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring required.
Reserpine + Insulin Lispro— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring required.
Reserpine + Insulin Lispro-Aabc— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.
Reserpine + Iobenguane I-123— Antihypertensive that depletes norepinephrine stores or inhibits reuptake, potentially decreasing iobenguane uptake and …
Reserpine + Landiolol— Catecholamine depletor; additive effect with beta-blockers may increase risk of hypotension, marked bradycardia, vertigo…
Reserpine + Metoprolol Succinate Er Tablets— Catecholamine-depleting drug may have additive effect with metoprolol, increasing risk of hypotension or marked bradycar…
Reserpine + Nateglinide— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.
Reserpine + Nortriptyline Hydrochloride— Administration with nortriptyline has been shown to produce a "stimulating" effect in some depressed patients. Close sup…
Reserpine + Phenoxybenzamine Hydrochloride— Phenoxybenzamine blocks hypothermia production by reserpine.
Reserpine + Phenytoin— May decrease phenytoin serum levels; monitoring of phenytoin levels recommended.
Reserpine + Phenytoin Sodium— May decrease phenytoin serum levels; monitoring of phenytoin levels recommended.

Reserpine + Carbidopa And Levodopa⛔Contraindicated

Use with carbidopa and levodopa is not recommended due to dopamine-depleting effects that may counteract the therapeutic benefit.

Reserpine + Deutetrabenazine⛔Contraindicated

Contraindicated; concomitant use risks major depletion of serotonin and norepinephrine. At least 20 days must elapse after stopping reserpine before starting deutetrabenazine.

Reserpine + Tetrabenazine⛔Contraindicated

Should not be used concomitantly. Must wait at least 20 days after stopping reserpine before starting tetrabenazine to avoid overdosage and major CNS depletion of serotonin and norepinephrine.

Reserpine + Acebutolol Hydrochloride⚠️Major

Additive effect may cause marked bradycardia or hypotension presenting as vertigo, syncope, or orthostatic changes in blood pressure.

Reserpine + Atenolol⚠️Major

Additive effect may cause hypotension and marked bradycardia, potentially producing vertigo, syncope, or postural hypotension.

Reserpine + Atenolol And Chlorthalidone⚠️Major

Catecholamine depletor may cause severe hypotension and marked bradycardia with vertigo, syncope, or postural hypotension.

Reserpine + Betaxolol⚠️Major

Catecholamine-depleting drugs may have additive effect with beta-blockers, causing hypotension, marked bradycardia, vertigo, syncope, or postural hypotension.

Reserpine + Betaxolol Hydrochloride⚠️Major

Catecholamine-depleting drug may have additive effects with beta-blockade, potentially causing hypotension, bradycardia, vertigo, syncope, or postural hypotension.

Reserpine + Bisoprolol Fumarate⚠️Major

Catecholamine-depleting drug that may produce excessive reduction of sympathetic activity when combined with bisoprolol fumarate; close monitoring required.

Reserpine + Bisoprolol Fumarate And Hydrochlorothiazide⚠️Major

Catecholamine-depleting drug that with bisoprolol's beta-adrenergic blocking action may produce excessive reduction of sympathetic activity. Close monitoring required.

Reserpine + Brimonidine Tartrate And Timolol Maleate⚠️Major

Catecholamine-depleting drug may produce additive effects causing hypotension and/or marked bradycardia, with risk of vertigo, syncope, or postural hypotension.

Reserpine + Carteolol Hydrochloride⚠️Major

Possible additive effects producing hypotension and/or marked bradycardia, which may result in vertigo, syncope, or postural hypotension. Close observation recommended.

Reserpine + Carvedilol⚠️Major

Hypotensive agent that may increase risk of hypotension and/or severe bradycardia when combined with carvedilol.

Reserpine + Carvedilol Phosphate⚠️Major

Catecholamine-depleting agent that may increase risk of hypotension and severe bradycardia when combined with carvedilol.

Reserpine + Cladribine⚠️Major

Potent BCRP, ENT1, and CNT3 transporter inhibitor may alter cladribine bioavailability, intracellular distribution, and renal elimination.

Reserpine + Dorzolamide Hydrochloride And Timolol Maleate Ophthalmic Solution⚠️Major

Catecholamine-depleting drug with additive effects producing hypotension and/or marked bradycardia, which may result in vertigo, syncope, or postural hypotension.

Reserpine + Dorzolamide Hydrochloride And Timolol Maleate Preservative Free⚠️Major

Catecholamine-depleting drug with additive effects; may produce hypotension and/or marked bradycardia, leading to vertigo, syncope, or postural hypotension.

Reserpine + Metoprolol⚠️Major

Catecholamine-depleting drug with additive effect on metoprolol causing hypotension or marked bradycardia, potentially producing vertigo, syncope, or postural hypotension.

Reserpine + Metoprolol Succinate⚠️Major

Catecholamine-depleting drug may have additive effect with metoprolol, causing hypotension, marked bradycardia, vertigo, syncope, or postural hypotension.

Reserpine + Metoprolol Succinate Er⚠️Major

Catecholamine depleting drug with additive effect when given with metoprolol succinate ER, may cause hypotension or marked bradycardia with vertigo, syncope, or postural hypotension.

Reserpine + Metoprolol Tartrate⚠️Major

Catecholamine-depleting drug with additive effect; may cause hypotension, marked bradycardia, vertigo, syncope, or postural hypotension.

Reserpine + Metoprolol Tartrate And Hydrochlorothiazide⚠️Major

Catecholamine-depleting drug that may have additive effect with metoprolol, increasing risk of hypotension or bradycardia.

Reserpine + Nadolol⚠️Major

Additive effect with nadolol; monitor closely for hypotension and/or excessive bradycardia (vertigo, syncope, postural hypotension).

Reserpine + Nebivolol⚠️Major

Catecholamine-depleting drug; concomitant use may produce excessive reduction of sympathetic activity. Closely monitor patients.

Reserpine + Nebivolol Hydrochloride⚠️Major

Catecholamine-depleting drug may produce excessive reduction of sympathetic activity when combined with nebivolol's β-blocking action.

Reserpine + Phenylephrine Hci⚠️Major

Centrally-acting sympatholytic agent that increases the pressor effect of phenylephrine hydrochloride.

Reserpine + Phenylephrine Hydrochloride⚠️Major

Centrally-acting sympatholytic agent that increases the pressor effect of phenylephrine hydrochloride.

Reserpine + Phenylephrine Hydrochloride Injection, Solution⚠️Major

Centrally-acting sympatholytic agent increases pressor effect of phenylephrine hydrochloride.

Reserpine + Pindolol⚠️Major

Additive hypotensive and bradycardic effects; may produce vertigo, syncope, or postural hypotension. Close observation required.

Reserpine + Propranolol Hydrochloride⚠️Major

Catecholamine-depleting effect may cause excessive reduction of sympathetic activity resulting in hypotension, bradycardia, vertigo, syncope, or orthostatic hypotension.

Reserpine + Sotalol Hydrochloride⚠️Major

Catecholamine-depleting agent; may produce excessive reduction of resting sympathetic nervous tone, causing hypotension and/or marked bradycardia.

Reserpine + Timolol⚠️Major

Additive effects with beta-blocker may produce hypotension and/or marked bradycardia, leading to vertigo, syncope, or postural hypotension.

Reserpine + Timolol Hemihydrate⚠️Major

Catecholamine-depleting drug with potential additive effects producing hypotension and/or marked bradycardia, which may result in vertigo, syncope, or postural hypotension.

Reserpine + Timolol Maleate⚠️Major

Close observation recommended when timolol is administered with reserpine due to possible additive effects and production of hypotension and/or marked bradycardia, which may result in vertigo, syncope, or postural hypotension.

Reserpine + Timolol Maleate Ophthalmic Gel Forming Solution 0.25%⚠️Major

Close observation recommended due to possible additive effects and production of hypotension and/or marked bradycardia, which may result in vertigo, syncope, or postural hypotension.

Reserpine + Amphetamine🟡Moderate

Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels, reducing efficacy.

Reserpine + Amphetamine Sulfate🟡Moderate

Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.

Reserpine + Desloratadine And Pseudoephedrine Sulfate🟡Moderate

Pseudoephedrine may reduce the antihypertensive effects of reserpine. Exercise caution when used concomitantly.

Reserpine + Dextroamphetamine🟡Moderate

Gastrointestinal acidifying agent lowers amphetamine absorption and blood levels, reducing efficacy.

Reserpine + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate🟡Moderate

Acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on clinical response.

Reserpine + Dextroamphetamine Sulfate🟡Moderate

Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.

Reserpine + Ephedrine Sulfate🟡Moderate

Antagonizes pressor effect of ephedrine. Carefully monitor blood pressure.

Reserpine + Fosphenytoin Sodium🟡Moderate

May decrease phenytoin serum levels; dose adjustment may be required.

Reserpine + Glimepiride🟡Moderate

May lead to either potentiation or weakening of glimepiride's glucose-lowering effect.

Reserpine + Glipizide🟡Moderate

May lead to either potentiation or weakening of glucose-lowering effect; may mask hypoglycemia signs.

Reserpine + Insulin Aspart Injection🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring required.

Reserpine + Insulin Aspart-Szjj🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.

Reserpine + Insulin Degludec🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.

Reserpine + Insulin Degludec And Liraglutide🟡Moderate

May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.

Reserpine + Insulin Detemir🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.

Reserpine + Insulin Glargine🟡Moderate

May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.

Reserpine + Insulin Glargine And Lixisenatide🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.

Reserpine + Insulin Glargine-Aglr🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.

Reserpine + Insulin Glargine-Yfgn🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.

Reserpine + Insulin Glulisine🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.

Reserpine + Insulin Human🟡Moderate

May blunt signs and symptoms of hypoglycemia; increased glucose monitoring required.

Reserpine + Insulin Icodec-Abae🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring required.

Reserpine + Insulin Lispro🟡Moderate

May blunt signs and symptoms of hypoglycemia; increased glucose monitoring required.

Reserpine + Insulin Lispro-Aabc🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.

Reserpine + Iobenguane I-123🟡Moderate

Antihypertensive that depletes norepinephrine stores or inhibits reuptake, potentially decreasing iobenguane uptake and causing false negative imaging results.

Reserpine + Landiolol🟡Moderate

Catecholamine depletor; additive effect with beta-blockers may increase risk of hypotension, marked bradycardia, vertigo, syncope, or postural hypotension. Monitor blood pressure and heart rate.

Reserpine + Metoprolol Succinate Er Tablets🟡Moderate

Catecholamine-depleting drug may have additive effect with metoprolol, increasing risk of hypotension or marked bradycardia.

Reserpine + Nateglinide🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.

Reserpine + Nortriptyline Hydrochloride🟡Moderate

Administration with nortriptyline has been shown to produce a "stimulating" effect in some depressed patients. Close supervision and careful dosage adjustment are required.

Reserpine + Phenoxybenzamine Hydrochloride🟡Moderate

Phenoxybenzamine blocks hypothermia production by reserpine.

Reserpine + Phenytoin🟡Moderate

May decrease phenytoin serum levels; monitoring of phenytoin levels recommended.

Reserpine + Phenytoin Sodium🟡Moderate

May decrease phenytoin serum levels; monitoring of phenytoin levels recommended.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.