Midodrine Hydrochloride has 21 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 11 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Linezolid, Mao Inhibitors, Monoamine Oxidase Inhibitors (Maois). Patients taking Midodrine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 21
- Contraindicated
- 3
- Major
- 11
Contraindicated (3)
- Midodrine Hydrochloride + Linezolid— Avoid use with midodrine.
- Midodrine Hydrochloride + Mao Inhibitors— Avoid use with midodrine.
- Midodrine Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Concomitant use with midodrine should be avoided.
Major (11)
- Midodrine Hydrochloride + Cardiac Glycosides— May enhance or precipitate bradycardia, A.V. block or arrhythmia when administered concomitantly with midodrine hydrochl…
- Midodrine Hydrochloride + Dihydroergotamine— Increases risk of hypertension when used concomitantly with midodrine. Avoid concomitant use or monitor blood pressure c…
- Midodrine Hydrochloride + Doxazosin— Alpha-adrenergic blocking agent can antagonize the effects of midodrine hydrochloride.
- Midodrine Hydrochloride + Droxidopa— Increases risk of hypertension when used concomitantly with midodrine. Avoid concomitant use or monitor blood pressure c…
- Midodrine Hydrochloride + Ephedrine— Increases risk of hypertension when used concomitantly with midodrine. Avoid concomitant use or monitor blood pressure c…
- Midodrine Hydrochloride + Fludrocortisone Acetate— Concomitant use increases potential for supine hypertension. Monitor closely and may minimize by reducing fludrocortison…
- Midodrine Hydrochloride + Phenylephrine Hci— Increases risk of hypertension when used concomitantly with midodrine. Avoid concomitant use or monitor blood pressure c…
- Midodrine Hydrochloride + Prazosin— Alpha-adrenergic blocking agent can antagonize the effects of midodrine hydrochloride.
- Midodrine Hydrochloride + Pseudoephedrine— Increases risk of hypertension when used concomitantly with midodrine. Avoid concomitant use or monitor blood pressure c…
- Midodrine Hydrochloride + Terazosin— Alpha-adrenergic blocking agent can antagonize the effects of midodrine hydrochloride.
- Midodrine Hydrochloride + Thyroid Hormones— Increases risk of hypertension when used concomitantly with midodrine. Avoid concomitant use or monitor blood pressure c…