Bupropion Hcl Er (Xl) has 22 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Carbamazepine, Clopidogrel, Desipramine. Patients taking Bupropion Hcl Er (Xl) should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Moderate
- 22
Moderate (22)
- Bupropion Hcl Er (Xl) + Carbamazepine— CYP2B6 inducer that may decrease bupropion exposure. Dose increase may be necessary but should not exceed maximum recomm…
- Bupropion Hcl Er (Xl) + Clopidogrel— CYP2B6 inhibitor that increases bupropion exposure and decreases hydroxybupropion exposure. Dosage adjustment of bupropi…
- Bupropion Hcl Er (Xl) + Desipramine— CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing desipramine exposure. Dose reduction may be neces…
- Bupropion Hcl Er (Xl) + Efavirenz— CYP2B6 inducer that decreases bupropion and hydroxybupropion exposure. Dosage increase of bupropion may be necessary but…
- Bupropion Hcl Er (Xl) + Flecainide— CYP2D6 substrate Type 1C antiarrhythmic. Bupropion inhibits CYP2D6, increasing flecainide exposure. Dose reduction may b…
- Bupropion Hcl Er (Xl) + Fluoxetine— CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing fluoxetine exposure. Dose reduction may be necess…
- Bupropion Hcl Er (Xl) + Haloperidol— CYP2D6 substrate antipsychotic. Bupropion inhibits CYP2D6, increasing haloperidol exposure. Dose reduction may be necess…
- Bupropion Hcl Er (Xl) + Imipramine— CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing imipramine exposure. Dose reduction may be necess…
- Bupropion Hcl Er (Xl) + Lopinavir— CYP2B6 inducer that decreases bupropion and hydroxybupropion exposure. Dosage increase of bupropion may be necessary but…
- Bupropion Hcl Er (Xl) + Metoprolol— CYP2D6 substrate beta-blocker. Bupropion inhibits CYP2D6, increasing metoprolol exposure. Dose reduction may be necessar…
- Bupropion Hcl Er (Xl) + Nortriptyline— CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing nortriptyline exposure. Dose reduction may be nec…
- Bupropion Hcl Er (Xl) + Paroxetine— CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing paroxetine exposure. Dose reduction may be necess…
- Bupropion Hcl Er (Xl) + Phenobarbital— CYP2B6 inducer that may decrease bupropion exposure. Dose increase may be necessary but should not exceed maximum recomm…
- Bupropion Hcl Er (Xl) + Phenytoin— CYP2B6 inducer that may decrease bupropion exposure. Dose increase may be necessary but should not exceed maximum recomm…
- Bupropion Hcl Er (Xl) + Propafenone— CYP2D6 substrate Type 1C antiarrhythmic. Bupropion inhibits CYP2D6, increasing propafenone exposure. Dose reduction may …
- Bupropion Hcl Er (Xl) + Risperidone— CYP2D6 substrate antipsychotic. Bupropion inhibits CYP2D6, increasing risperidone exposure. Dose reduction may be necess…
- Bupropion Hcl Er (Xl) + Ritonavir— CYP2B6 inducer that decreases bupropion and hydroxybupropion exposure. Dosage increase of bupropion may be necessary but…
- Bupropion Hcl Er (Xl) + Sertraline— CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing sertraline exposure. Dose reduction may be necess…
- Bupropion Hcl Er (Xl) + Tamoxifen— Requires CYP2D6 activation for efficacy. Bupropion's CYP2D6 inhibition may reduce tamoxifen efficacy, potentially requir…
- Bupropion Hcl Er (Xl) + Thioridazine— CYP2D6 substrate antipsychotic. Bupropion inhibits CYP2D6, increasing thioridazine exposure. Dose reduction may be neces…
- Bupropion Hcl Er (Xl) + Ticlopidine— CYP2B6 inhibitor that increases bupropion exposure and decreases hydroxybupropion exposure. Dosage adjustment of bupropi…
- Bupropion Hcl Er (Xl) + Venlafaxine— CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing venlafaxine exposure. Dose reduction of venlafaxi…