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Does Fluoxetine Interact with Bupropion Hcl Er Xl?

CDI records a moderate classification for Fluoxetine and Bupropion Hcl Er Xl. The stored summary is: CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing fluoxetine exposure. Dose reduction may be necessary. The mechanism involves cyp2d6 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity: Moderate
Management: Monitor for effects
Data Source: U.S. FDA via OpenFDA

Recorded Mechanism

CYP2D6 inhibition

What To Tell Your Doctor or Pharmacist

If you are taking Fluoxetine and your doctor is considering prescribing Bupropion Hcl Er Xl (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Fluoxetine(Symbyax)+💊 Bupropion Hcl Er Xl(Wellbutrin)

Severity & Interaction Details

🟡

moderate

Be aware — moderate interaction

Documented interaction with manageable risk. May require dose adjustment or monitoring.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

NLP:bupropion hcl er (xl)

What this means in plain English

CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing fluoxetine exposure. Dose reduction may be necessary.

About Fluoxetine and Bupropion Hcl Er Xl

You may recognize them by the brand names Symbyax and Wellbutrin. Both Fluoxetine and Bupropion Hcl Er Xl carry an FDA boxed warning — the agency's most serious safety designation.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:bupropion hcl er (xl)

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.