Does Abacavir Lamivudine And Zidovudine Interact with Doxorubicin?
Abacavir Lamivudine And Zidovudine and Doxorubicin have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use with zidovudine should be avoided due to demonstrated in vitro antagonistic relationship. The mechanism involves antagonistic relationship demonstrated in vitro. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Abacavir Lamivudine And Zidovudine Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Abacavir Lamivudine And Zidovudine and Doxorubicin occurs because antagonistic relationship demonstrated in vitro. Clinically, this means concomitant use with zidovudine should be avoided due to demonstrated in vitro antagonistic relationship. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.
What To Tell Your Doctor or Pharmacist
If you are taking Abacavir Lamivudine And Zidovudine and your doctor is considering prescribing Doxorubicin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider