Does Acetaminophen Interact with Alcohol?
Acetaminophen and Alcohol have a moderate drug interaction according to U.S. FDA drug labeling data. Ethanol has complex effects on acetaminophen metabolism; excessive alcohol can induce hepatic cytochromes increasing hepatotoxic potential, while also acting as competitive inhibitor of acetaminophen metabolism. The mechanism involves hepatic cyp2e1 induction and competitive inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Acetaminophen and Alcohol occurs because hepatic cyp2e1 induction and competitive inhibition. Clinically, this means ethanol has complex effects on acetaminophen metabolism; excessive alcohol can induce hepatic cytochromes increasing hepatotoxic potential, while also acting as competitive inhibitor of acetaminophen metabolism. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Acetaminophen and your doctor is considering prescribing Alcohol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider