Home›Acetaminophen

Acetaminophen

Also known as: Acetaminophen

Route: Intravenous

70 interactions on record⛔ Black Box Warning

Acetaminophen has 70 known drug interactions based on U.S. FDA drug labeling data. 31 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Articaine Hydrochloride And Epinephrine, Articaine Hydrochloride And Epinephrine Bitartrate, Benzocaine, Butamben, And Tetracaine Hydrochloride. Patients taking Acetaminophen should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 70
Major: 31
Moderate: 30
Minor: 9

Major (31)

Acetaminophen + Articaine Hydrochloride And Epinephrine— Increased risk of methemoglobinemia when concurrently exposed to articaine.
Acetaminophen + Articaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed to this agent.
Acetaminophen + Benzocaine, Butamben, And Tetracaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed to this oxidizing agent with local anesthetics.
Acetaminophen + Bupivacaine And Meloxicam— Increased risk of methemoglobinemia when local anesthetics are used concomitantly with acetaminophen and other drugs.
Acetaminophen + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
Acetaminophen + Dapsone— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
Acetaminophen + Dapsone Gel, 5%— Concomitant use may increase risk of developing methemoglobinemia. Monitor closely.
Acetaminophen + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Associated with increased methemoglobinemia risk when used with ropivacaine.
Acetaminophen + Isoniazid— Isoniazid induces P-450IIE1 enzyme, increasing conversion of acetaminophen to toxic metabolites and potentiating hepatot…
Acetaminophen + Lidocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
Acetaminophen + Lidocaine 5%— May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Acetaminophen + Lidocaine And Capsaicin— Drug that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.
Acetaminophen + Lidocaine And Prilocaine— Increased risk of methemoglobinemia when concurrently exposed.
Acetaminophen + Lidocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Acetaminophen + Lidocaine Hydrochloride And Epinephrine Bitartrate— Associated with increased methemoglobinemia risk when used concurrently with local anesthetics.
Acetaminophen + Lidocaine Hydrochloride And Hydrocortisone Acetate— Increased risk of methemoglobinemia when local anesthetic is concurrently exposed to acetaminophen.
Acetaminophen + Lidocaine Hydrochloride Monohydrate— Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.
Acetaminophen + Lidocaine Patch 5%— Increased risk of methemoglobinemia; drugs associated with methemoglobinemia when used with local anesthetics.
Acetaminophen + Lidocaine, Isopropyl Alcohol— Increased risk of methemoglobinemia when used with lidocaine.
Acetaminophen + Lidocaine, Menthol— Increased risk of methemoglobinemia when lidocaine is concurrently exposed to acetaminophen.
Acetaminophen + Lidothol Patch— Increased risk of methemoglobinemia when local anesthetics are concurrently exposed to oxidizing agents.
Acetaminophen + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed.
Acetaminophen + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
Acetaminophen + Metyrapone— Metyrapone inhibits glucuronidation of acetaminophen, decreasing elimination and increasing risk of adverse reactions. A…
Acetaminophen + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when penicillin is concurrently administered with acetaminophen.
Acetaminophen + Prilocaine Hcl And Epinephrine— Increased risk of methemoglobinemia when prilocaine is concurrently exposed to acetaminophen.
Acetaminophen + Prilocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with prilocaine.
Acetaminophen + Ropivacaine Hydrochloride— Increased risk of developing methemoglobinemia when concurrently exposed to acetaminophen.
Acetaminophen + Triamcinolone Acetonide— Increased risk of methemoglobinemia when concurrently exposed.
Acetaminophen + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
Acetaminophen + Trubrexa Patch Er— Increased risk of methemoglobinemia when used with Trubrexa Transdermal Patch.

Moderate (30)

Acetaminophen + Alcohol— Ethanol has complex effects on acetaminophen metabolism; excessive alcohol can induce hepatic cytochromes increasing hep…
Acetaminophen + Bupivacaine— May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
Acetaminophen + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
Acetaminophen + Bupivacaine Hydrochloride With Dextrose— Increased risk of developing methemoglobinemia when concurrently exposed.
Acetaminophen + Busulfan— Use within 72 hours prior to or concurrent with busulfan may result in reduced busulfan clearance by decreasing glutathi…
Acetaminophen + Desogestrel And Ethinyl Estradiol And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Acetaminophen + Diflunisal— Concomitant administration resulted in approximately 50% increase in plasma levels of acetaminophen. Should be used caut…
Acetaminophen + Drospirenone And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Acetaminophen + Drospirenone, Ethinyl Estradiol And Levomefolate Calcium And Levomefolate Calcium— May increase plasma ethinyl estradiol concentrations, possibly through inhibition of conjugation.
Acetaminophen + Drospirenone/Ethinyl Estradiol/Levomefolate Calcium And Levomefolate Calcium— May increase plasma ethinyl estradiol concentrations possibly by inhibition of conjugation.
Acetaminophen + Etonogestrel And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Acetaminophen + Etonogestrel And Ethinyl Estradiol Vaginal Ring— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Acetaminophen + Exenatide— Exenatide slows gastric emptying, potentially reducing the rate of absorption of orally administered drugs like acetamin…
Acetaminophen + Insulin Glargine And Lixisenatide— Lixisenatide delays gastric emptying which may impact absorption. Should be taken at least 1 hour prior to or 11 hours a…
Acetaminophen + Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate— Acetaminophen may increase plasma ethinyl estradiol levels.
Acetaminophen + Levonorgestrel/Ethinyl Estradiol And Ethinyl Estradiol— May increase plasma ethinyl estradiol levels.
Acetaminophen + Lidocaine And Tetracaine— Drug that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
Acetaminophen + Marcaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
Acetaminophen + Metoclopramide— Metoclopramide may increase the rate and/or extent of absorption of acetaminophen from the small bowel.
Acetaminophen + Metoclopramide Hydrochloride— Metoclopramide may increase the rate and/or extent of absorption of acetaminophen from the small bowel.
Acetaminophen + Nicotine— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
Acetaminophen + Norelgestromin And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Acetaminophen + Norethindrone Acetate, Ethinyl Estradiol And Ferrous Fumarate— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Acetaminophen + Norethindrone Acetate/Ethinyl Estradiol— May increase plasma ethinyl estradiol concentration, possibly by inhibition of conjugation.
Acetaminophen + Norethindrone And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations.
Acetaminophen + Norgestimate And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Acetaminophen + Probenecid— Probenecid increases plasma elimination half-life and concentrations of acetaminophen; lower dosage may be required.
Acetaminophen + Probenecid And Colchicine— Probenecid increases mean plasma elimination half-life and plasma concentrations of acetaminophen; use lower dosages cau…
Acetaminophen + Segesterone Acetate And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Acetaminophen + Warfarin Sodium— Chronic oral acetaminophen use at 4000 mg/day increases INR in some patients stabilized on warfarin. More frequent INR a…

Minor (9)

Acetaminophen + Argatroban— No drug-drug interactions have been demonstrated between argatroban and acetaminophen.
Acetaminophen + Finasteride— Used concomitantly in clinical studies without evidence of clinically significant adverse interactions.
Acetaminophen + Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets— Acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Acetaminophen + Norgestrel And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations.
Acetaminophen + Rimantadine Hydrochloride— Co-administration reduced peak concentration and AUC values for rimantadine by approximately 11%.
Acetaminophen + Sulindac— Acetaminophen had no effect on the plasma levels of sulindac or its sulfide metabolite.
Acetaminophen + Terazosin— Terazosin has been used concomitantly with acetaminophen in at least 50 patients with no interactions observed.
Acetaminophen + Terazosin Hydrochloride— Used concomitantly with terazosin in at least 50 patients with no interactions observed.
Acetaminophen + Treprostinil— Co-administration did not show clinically significant effect on treprostinil pharmacokinetics.

Acetaminophen + Articaine Hydrochloride And Epinephrine⚠️Major

Increased risk of methemoglobinemia when concurrently exposed to articaine.

Acetaminophen + Articaine Hydrochloride And Epinephrine Bitartrate⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this agent.

Acetaminophen + Benzocaine, Butamben, And Tetracaine Hydrochloride⚠️Major

Increased risk of methemoglobinemia when concurrently exposed to this oxidizing agent with local anesthetics.

Acetaminophen + Bupivacaine And Meloxicam⚠️Major

Increased risk of methemoglobinemia when local anesthetics are used concomitantly with acetaminophen and other drugs.

Acetaminophen + Bupivacaine Hydrochloride⚠️Major

Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.

Acetaminophen + Dapsone⚠️Major

Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.

Acetaminophen + Dapsone Gel, 5%⚠️Major

Concomitant use may increase risk of developing methemoglobinemia. Monitor closely.

Acetaminophen + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine⚠️Major

Associated with increased methemoglobinemia risk when used with ropivacaine.

Acetaminophen + Isoniazid⚠️Major

Isoniazid induces P-450IIE1 enzyme, increasing conversion of acetaminophen to toxic metabolites and potentiating hepatotoxicity. Severe acetaminophen toxicity has been reported.

Acetaminophen + Lidocaine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine.

Acetaminophen + Lidocaine 5%⚠️Major

May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Acetaminophen + Lidocaine And Capsaicin⚠️Major

Drug that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.

Acetaminophen + Lidocaine And Prilocaine⚠️Major

Increased risk of methemoglobinemia when concurrently exposed.

Acetaminophen + Lidocaine Hydrochloride⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Acetaminophen + Lidocaine Hydrochloride And Epinephrine Bitartrate⚠️Major

Associated with increased methemoglobinemia risk when used concurrently with local anesthetics.

Acetaminophen + Lidocaine Hydrochloride And Hydrocortisone Acetate⚠️Major

Increased risk of methemoglobinemia when local anesthetic is concurrently exposed to acetaminophen.

Acetaminophen + Lidocaine Hydrochloride Monohydrate⚠️Major

Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.

Acetaminophen + Lidocaine Patch 5%⚠️Major

Increased risk of methemoglobinemia; drugs associated with methemoglobinemia when used with local anesthetics.

Acetaminophen + Lidocaine, Isopropyl Alcohol⚠️Major

Increased risk of methemoglobinemia when used with lidocaine.

Acetaminophen + Lidocaine, Menthol⚠️Major

Increased risk of methemoglobinemia when lidocaine is concurrently exposed to acetaminophen.

Acetaminophen + Lidothol Patch⚠️Major

Increased risk of methemoglobinemia when local anesthetics are concurrently exposed to oxidizing agents.

Acetaminophen + Marcaine, Lidocaine, Kenalog, Povidone Iodine⚠️Major

Increased risk of methemoglobinemia when concurrently exposed.

Acetaminophen + Mepivacaine Hydrochloride⚠️Major

Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.

Acetaminophen + Metyrapone⚠️Major

Metyrapone inhibits glucuronidation of acetaminophen, decreasing elimination and increasing risk of adverse reactions. Avoid concomitant use.

Acetaminophen + Penicillin G Benzathine And Penicillin G Procaine⚠️Major

Increased risk of methemoglobinemia when penicillin is concurrently administered with acetaminophen.

Acetaminophen + Prilocaine Hcl And Epinephrine⚠️Major

Increased risk of methemoglobinemia when prilocaine is concurrently exposed to acetaminophen.

Acetaminophen + Prilocaine Hydrochloride⚠️Major

Increased risk of methemoglobinemia when used concurrently with prilocaine.

Acetaminophen + Ropivacaine Hydrochloride⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to acetaminophen.

Acetaminophen + Triamcinolone Acetonide⚠️Major

Increased risk of methemoglobinemia when concurrently exposed.

Acetaminophen + Triethanolamine Salicylate⚠️Major

Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.

Acetaminophen + Trubrexa Patch Er⚠️Major

Increased risk of methemoglobinemia when used with Trubrexa Transdermal Patch.

Acetaminophen + Alcohol🟡Moderate

Ethanol has complex effects on acetaminophen metabolism; excessive alcohol can induce hepatic cytochromes increasing hepatotoxic potential, while also acting as competitive inhibitor of acetaminophen metabolism.

Acetaminophen + Bupivacaine🟡Moderate

May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.

Acetaminophen + Bupivacaine Hydrochloride And Epinephrine Bitartrate🟡Moderate

Increased risk of methemoglobinemia when concurrently exposed.

Acetaminophen + Bupivacaine Hydrochloride With Dextrose🟡Moderate

Increased risk of developing methemoglobinemia when concurrently exposed.

Acetaminophen + Busulfan🟡Moderate

Use within 72 hours prior to or concurrent with busulfan may result in reduced busulfan clearance by decreasing glutathione levels.

Acetaminophen + Desogestrel And Ethinyl Estradiol And Ethinyl Estradiol🟡Moderate

May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.

Acetaminophen + Diflunisal🟡Moderate

Concomitant administration resulted in approximately 50% increase in plasma levels of acetaminophen. Should be used cautiously with careful monitoring due to hepatotoxicity risk of acetaminophen at high doses.

Acetaminophen + Drospirenone And Ethinyl Estradiol🟡Moderate

May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.

Acetaminophen + Drospirenone, Ethinyl Estradiol And Levomefolate Calcium And Levomefolate Calcium🟡Moderate

May increase plasma ethinyl estradiol concentrations, possibly through inhibition of conjugation.

Acetaminophen + Drospirenone/Ethinyl Estradiol/Levomefolate Calcium And Levomefolate Calcium🟡Moderate

May increase plasma ethinyl estradiol concentrations possibly by inhibition of conjugation.

Acetaminophen + Etonogestrel And Ethinyl Estradiol🟡Moderate

May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.

Acetaminophen + Etonogestrel And Ethinyl Estradiol Vaginal Ring🟡Moderate

May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.

Acetaminophen + Exenatide🟡Moderate

Exenatide slows gastric emptying, potentially reducing the rate of absorption of orally administered drugs like acetaminophen. Use caution with oral medications.

Acetaminophen + Insulin Glargine And Lixisenatide🟡Moderate

Lixisenatide delays gastric emptying which may impact absorption. Should be taken at least 1 hour prior to or 11 hours after SOLIQUA administration.

Acetaminophen + Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate🟡Moderate

Acetaminophen may increase plasma ethinyl estradiol levels.

Acetaminophen + Levonorgestrel/Ethinyl Estradiol And Ethinyl Estradiol🟡Moderate

May increase plasma ethinyl estradiol levels.

Acetaminophen + Lidocaine And Tetracaine🟡Moderate

Drug that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.

Acetaminophen + Marcaine, Kenalog, Povidone Iodine🟡Moderate

Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.

Acetaminophen + Metoclopramide🟡Moderate

Metoclopramide may increase the rate and/or extent of absorption of acetaminophen from the small bowel.

Acetaminophen + Metoclopramide Hydrochloride🟡Moderate

Metoclopramide may increase the rate and/or extent of absorption of acetaminophen from the small bowel.

Acetaminophen + Nicotine🟡Moderate

Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.

Acetaminophen + Norelgestromin And Ethinyl Estradiol🟡Moderate

May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.

Acetaminophen + Norethindrone Acetate, Ethinyl Estradiol And Ferrous Fumarate🟡Moderate

May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.

Acetaminophen + Norethindrone Acetate/Ethinyl Estradiol🟡Moderate

May increase plasma ethinyl estradiol concentration, possibly by inhibition of conjugation.

Acetaminophen + Norethindrone And Ethinyl Estradiol🟡Moderate

May increase plasma ethinyl estradiol concentrations.

Acetaminophen + Norgestimate And Ethinyl Estradiol🟡Moderate

May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.

Acetaminophen + Probenecid🟡Moderate

Probenecid increases plasma elimination half-life and concentrations of acetaminophen; lower dosage may be required.

Acetaminophen + Probenecid And Colchicine🟡Moderate

Probenecid increases mean plasma elimination half-life and plasma concentrations of acetaminophen; use lower dosages cautiously.

Acetaminophen + Segesterone Acetate And Ethinyl Estradiol🟡Moderate

May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.

Acetaminophen + Warfarin Sodium🟡Moderate

Chronic oral acetaminophen use at 4000 mg/day increases INR in some patients stabilized on warfarin. More frequent INR assessment may be appropriate during concurrent use.

Acetaminophen + Argatroban🟢Minor

No drug-drug interactions have been demonstrated between argatroban and acetaminophen.

Acetaminophen + Finasteride🟢Minor

Used concomitantly in clinical studies without evidence of clinically significant adverse interactions.

Acetaminophen + Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets🟢Minor

Acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.

Acetaminophen + Norgestrel And Ethinyl Estradiol🟢Minor

May increase plasma ethinyl estradiol concentrations.

Acetaminophen + Rimantadine Hydrochloride🟢Minor

Co-administration reduced peak concentration and AUC values for rimantadine by approximately 11%.

Acetaminophen + Sulindac🟢Minor

Acetaminophen had no effect on the plasma levels of sulindac or its sulfide metabolite.

Acetaminophen + Terazosin🟢Minor

Terazosin has been used concomitantly with acetaminophen in at least 50 patients with no interactions observed.

Acetaminophen + Terazosin Hydrochloride🟢Minor

Used concomitantly with terazosin in at least 50 patients with no interactions observed.

Acetaminophen + Treprostinil🟢Minor

Co-administration did not show clinically significant effect on treprostinil pharmacokinetics.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.