Does Acetazolamide Interact with Amoxicillin?
Acetazolamide and Amoxicillin have a moderate drug interaction according to U.S. FDA drug labeling data. Sulfonamides may interfere with bactericidal effects of amoxicillin, though clinical significance is not well documented. The mechanism involves interference with bactericidal effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Acetazolamide Class
- Carbonic Anhydrase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Acetazolamide and Amoxicillin occurs because interference with bactericidal effects. Clinically, this means sulfonamides may interfere with bactericidal effects of amoxicillin, though clinical significance is not well documented. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Acetazolamide and your doctor is considering prescribing Amoxicillin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider