Does Acetazolamide Interact with Levothyroxine Sodium?
The levothyroxine label lists sulfonamides among drugs that may decrease thyroid hormone secretion. It does not name acetazolamide. This class statement does not establish the acetazolamide-specific association in CDI.
Label evidence and limitations
Specific-drug mapping not established. The stored moderate classification and specific-drug mapping require review. An unconfirmed mapping is not evidence that the combination is safe.
Product scope: Oral levothyroxine sodium tablets; a thyroid-secretion class statement.
Read the DailyMed label: Levothyroxine Sodium Tablets, USP
Section: Drug Interactions — Drugs that alter thyroid hormone secretion. Compared version 3, label date 2020-03-01. The linked label may be updated after this comparison.
This comparison uses the label identifier saved with the CDI record. The compared version may be newer than the original extraction.
AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.
- Stored CDI classification
- Moderate
- Acetazolamide Class
- Carbonic Anhydrase Inhibitor
- Management
- Confirm exact products with your pharmacist
- Data Source
- Product label via NLM DailyMed
What To Tell Your Doctor or Pharmacist
If you are taking Acetazolamide and your doctor is considering prescribing Levothyroxine Sodium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider