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Does Allopurinol Interact with Pegloticase?

Allopurinol and Pegloticase have a contraindicated drug interaction according to U.S. FDA drug labeling data. Discontinue and refrain from initiating treatment with allopurinol when using pegloticase. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Allopurinol Class
Xanthine Oxidase Inhibitor
Pegloticase Class
Uric Acid-specific Enzyme
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Allopurinol and your doctor is considering prescribing Pegloticase (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Allopurinol(Zyloprim)+💊 Pegloticase(Krystexxa)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Xanthine Oxidase Inhibitor
Drug B class
Uric Acid-specific Enzyme
Source
NLP:allopurinol

What this means in plain English

Discontinue and refrain from initiating treatment with allopurinol when using pegloticase.

About Allopurinol and Pegloticase

Allopurinol is a Xanthine Oxidase Inhibitor, while Pegloticase is an Uric Acid-specific Enzyme. You may recognize them by the brand names Zyloprim and Krystexxa. Allopurinol is taken by mouth, whereas Pegloticase is given by intravenous (IV) infusion. Both Allopurinol and Pegloticase carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.