Does Alogliptin Interact with Sulfonylurea?
Alogliptin and Sulfonylurea have a moderate drug interaction according to U.S. FDA drug labeling data. Coadministration may increase hypoglycemia risk. Lower dosages of sulfonylurea may be required when used with alogliptin. The mechanism involves insulin secretagogues cause hypoglycemia; additive effect with alogliptin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Alogliptin and Sulfonylurea occurs because insulin secretagogues cause hypoglycemia; additive effect with alogliptin. Clinically, this means coadministration may increase hypoglycemia risk. lower dosages of sulfonylurea may be required when used with alogliptin. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Alogliptin and your doctor is considering prescribing Sulfonylurea (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider