Alogliptin And Pioglitazone + Gemfibrozil Interaction
Majorinteraction on record
Description
Strong CYP2C8 inhibitor significantly increases pioglitazone exposure and half-life. Maximum recommended dose limited to 25 mg alogliptin and 15 mg pioglitazone daily.
Mechanism
CYP2C8 inhibition increases pioglitazone AUC and half-life
Source: NLP:alogliptin benzoate and pioglitazone hydrochloride