Does Amiodarone Hydrochloride Interact with Protease Inhibitors?
Contraindicated interaction. Increased exposure of amiodarone via CYP450 inhibition. Avoid concomitant use.
Source & how this summary was prepared
This interaction summary was extracted from FDA drug labeling through openFDA, using automated processing and AI assistance. NIH/NLM RxNorm helps organize drug names.
Read the saved source label on DailyMed →
A separate current-label comparison has not been recorded for this page. Read about our extraction process.
- Interaction classification
- Contraindicated
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How this interaction works
CYP450 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Amiodarone Hydrochloride and your doctor is considering prescribing Protease Inhibitors (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider