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Does Amlodipine And Atorvastatin Interact with Glecaprevir And Pibrentasvir?

Amlodipine And Atorvastatin and Glecaprevir And Pibrentasvir have a contraindicated drug interaction according to U.S. FDA drug labeling data. Avoid atorvastatin due to increased risk of myopathy and rhabdomyolysis. The mechanism involves strong cyp3a4 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Glecaprevir And Pibrentasvir Class
Hepatitis C Virus NS5A Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Amlodipine And Atorvastatin and Glecaprevir And Pibrentasvir occurs because strong cyp3a4 inhibition. Clinically, this means avoid atorvastatin due to increased risk of myopathy and rhabdomyolysis. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Amlodipine And Atorvastatin and your doctor is considering prescribing Glecaprevir And Pibrentasvir (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Amlodipine And Atorvastatin(Amlodipine And Atorvastatin)+💊 Glecaprevir And Pibrentasvir(Mavyret)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Hepatitis C Virus NS5A Inhibitor
Source
NLP:amlodipine besylate and atorvastatin calcium

What this means in plain English

Avoid atorvastatin due to increased risk of myopathy and rhabdomyolysis.

What the FDA label says

"Strong CYP3A4 inhibition"

📖 Source: NLP:amlodipine besylate and atorvastatin calcium

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.