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Does Amlodipine And Atorvastatin Interact with Ledipasvir?

Amlodipine And Atorvastatin and Ledipasvir have a unknown drug interaction according to U.S. FDA drug labeling data. Cases of myopathy and rhabdomyolysis have been reported with concomitant use of ledipasvir plus sofosbuvir with atorvastatin. Consider the risk/benefit of concomitant use of ledipasvir plus sofosbuvir with atorvastatin. Examples: Tipranavir plus ritonavir, glecaprevir plus pibrentasvir, lopinavir plus ritonavir, simeprevir, saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, fosamprenavir plus ritonavir, elbasvir plus grazoprevir, letermovir, nelfinavir, and ledipasvir plus sofosbuvir . Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Unknown
Management: Consult your pharmacist
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Amlodipine And Atorvastatin and your doctor is considering prescribing Ledipasvir (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Amlodipine And Atorvastatin(Caduet)+💊 Ledipasvir(Harvoni)

Severity & Interaction Details

ℹ️

unknown

Interaction documented — severity unclassified

The FDA label notes an interaction but the severity is not classified in our dataset.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

FDA drug label - amlodipine and atorvastatin

What this means in plain English

Cases of myopathy and rhabdomyolysis have been reported with concomitant use of ledipasvir plus sofosbuvir with atorvastatin. Consider the risk/benefit of concomitant use of ledipasvir plus sofosbuvir with atorvastatin. Examples: Tipranavir plus ritonavir, glecaprevir plus pibrentasvir, lopinavir plus ritonavir, simeprevir, saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, fosamprenavir plus ritonavir, elbasvir plus grazoprevir, letermovir, nelfinavir, and ledipasvir plus sofosbuvir .

About Amlodipine And Atorvastatin and Ledipasvir

You may recognize them by the brand names Caduet and Harvoni. Amlodipine And Atorvastatin is taken by mouth.

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Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.