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Does Amlodipine And Benazepril Hydrochloride Interact with Ibuprofen?

The amlodipine/benazepril label warns that NSAIDs can reduce the antihypertensive effect and worsen renal function in susceptible patients. This is an NSAID-class statement; ibuprofen is not individually named in the compared passage.

Label evidence and limitations

Class-level label evidence. The renal warning specifically emphasizes elderly, volume-depleted, or renally impaired patients. The passage is not an individual risk estimate or validation of CDI’s severity category.

Product scope: Oral amlodipine/benazepril combination capsules; NSAID-class interaction.

Read the DailyMed label: These highlights do not include all the information needed to use Amlodipine and Benazepril Hydrochloride Capsules, safely and effectively. See full prescribing information for Amlodipine and Benazepril Hydrochloride Capsules. AMLODIPINE and BENAZEPRIL Hydrochloride Capsules for oral use Initial U.S. Approval: 1995
Section: 7.1 Drug-Drug Interactions — Nonsteroidal Anti-Inflammatory Agents. Compared version 13, label date 2023-05-03. The linked label may be updated after this comparison.

This comparison uses the label identifier saved with the CDI record. The compared version may be newer than the original extraction.

AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.

Stored CDI classification: Major
Ibuprofen Class: Nonsteroidal Anti-inflammatory Drug
Management: Confirm exact products with your pharmacist
Data Source: Product label via NLM DailyMed

What To Tell Your Doctor or Pharmacist

If you are taking Amlodipine And Benazepril Hydrochloride and your doctor is considering prescribing Ibuprofen (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Amlodipine And Benazepril Hydrochloride(Lotrel)+💊 Ibuprofen(Ibu)

Severity & Interaction Details

⚠️

Stored CDI classification: major

Class-level label evidence

The renal warning specifically emphasizes elderly, volume-depleted, or renally impaired patients. The passage is not an individual risk estimate or validation of CDI’s severity category.

Stored CDI scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

Nonsteroidal Anti-inflammatory Drug

Source

NLP:amlodipine besylate and benazepril hydrochloride

How to interpret this source comparison

The renal warning specifically emphasizes elderly, volume-depleted, or renally impaired patients. The passage is not an individual risk estimate or validation of CDI’s severity category.

About Amlodipine And Benazepril Hydrochloride and Ibuprofen

Ibuprofen is a Nonsteroidal Anti-inflammatory Drug. Amlodipine And Benazepril Hydrochloride is also sold under the brand name Lotrel. Both Amlodipine And Benazepril Hydrochloride and Ibuprofen carry an FDA boxed warning — the agency's most serious safety designation.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:amlodipine besylate and benazepril hydrochloride

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.