Does Amoxicillin And Clavulanate Potassium Interact with Probenecid?
CDI records a contraindicated classification for Amoxicillin And Clavulanate Potassium and Probenecid. The stored summary is: Probenecid decreases renal tubular secretion of amoxicillin, resulting in increased and prolonged blood concentrations. Co-administration is not recommended. The mechanism involves decreased renal tubular secretion of amoxicillin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Amoxicillin And Clavulanate Potassium Class
- beta Lactamase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Decreased renal tubular secretion of amoxicillin
What To Tell Your Doctor or Pharmacist
If you are taking Amoxicillin And Clavulanate Potassium and your doctor is considering prescribing Probenecid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider